Research progress of G-test in the diagnosis of invasive fungal diseases

doi:10.3969/j.issn.1673-8640.2019.09.021

Abstract

Abstract:

In the past 30 years,the morbidity and mortality of invasive fungal diseases（IFD） are increasing. Considering the non-specific manifestations,limited treatment and high mortality,sensitive and specific laboratory diagnostic methods are of significance to prevent and treat IFD. As a fast and non-invasive method,G-test plays a role in the diagnosis of IFD. The main progresses of G-test in the last 5 years are focused in this review.

Key words: G-test, 1,3-β-D-glucan, Invasive fungal disease, Diagnosis

CLC Number:

R446.1

LI Zhanjia, ZHAI Hongyan, CHEN Shuiping. Research progress of G-test in the diagnosis of invasive fungal diseases[J]. Laboratory Medicine, 2019, 34(9): 859-863.

References 49

[1]	中国侵袭性真菌感染工作组. 血液病/恶性肿瘤患者侵袭性真菌病的诊断标准与治疗原则(第五次修订版)[J]. 中华内科杂志,2017,56(6):453-459.
[2]	LIEPINS J,KOVAOVA E,SHVIRKSTS K,et al.Drying enhances immunoactivity of spent brewer's yeast cell wall β-d-glucans[J]. J Biotechnol,2015,206:12-16.
[3]	TRAN T,BEAL S G.Application of the 1,3-beta-D-glucan(fungitell) assay in the diagnosis of invasive fungal infections[J]. Arch Pathol Lab Med,2016,140(2):181-185.
[4]	薛知信,刘娟娟,王保学,等. 碱处理法提高血清1,3-β-D-葡聚糖检测的特异性[J]. 检验医学,2017,32(1):48-51.
[5]	MIKULSKA M,GIACOBBE D R,FURFARO E,et al. Lower sensitivity of serum(1,3)-β-d-glucan for the diagnosis of candidaemia due to Candida parapsilosis[J]. Clin Microbiol Infect,2016,22(7):646.e5-58.
[6]	DE PAUW B,WALSH T J,DONNELLY J P,et al.Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group(EORTC/MSG) Consensus Group[J]. Clin Infect Dis,2008,46(12):1813-1821.
[7]	KARAGEORGOPOULOS D E,VOULOUMANOU E K,NTZIORA F,et al.β-D-glucan assay for the diagnosis of invasive fungal infections:a meta-analysis[J]. Clin Infect Dis,2011,52(6):750-770.
[8]	LEVESQUE E,RIZK F,NOORAH Z,et al. Detection of(1,3)-β-d-glucan for the diagnosis of invasive fungal infection in liver transplant recipients[J]. Int J Mol Sci,2017,18(4):pii:E862.
[9]	REISCHIES F M,PRATTES J,WOELFLER A,et al.Diagnostic performance of 1,3-beta-D-glucan serum screening in patients receiving hematopoietic stem cell transplantation[J]. Transpl Infect Dis,2016,18(3):466-470.
[10]	TALENTO A F,DUNNE K,JOYCE E A,et al.A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit[J]. J Crit Care,2017,40:119-127.
[11]	LAMOTH F.Galactomannan and 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Aspergillosis[J]. Journal of Fungi,2016,2(3):22.
[12]	ALEXANDER B D,SMITH P B,DAVIS R D,et al.The (1,3)){beta}-D-glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation[J]. J Clin Microbiol,2010,48(11):4083-4088.
[13]	SON H J,SUNG H,PARK S Y,et al.Diagnostic performance of the(1-3)-β-D-glucan assay in patients with Pneumocystis jirovecii compared with those with candidiasis,aspergillosis,mucormycosis,and tuberculosis,and healthy volunteers[J]. PLoS One,2017,12(11):e0188860.
[14]	OSTROSKY-ZEICHNER L,ALEXANDER B D,KETT D H,et al.Multicenter clinical evaluation of the(1→3)-beta-D-glucan assay as an aid to diagnosis of fungal infections in humans[J]. Clin Infect Dis,2005,41(5):654-659.
[15]	HE S,HANG J P,ZHANG L,et al.A systematic review and meta-analysis of diagnostic accuracy of serum 1,3-β-D-glucan for invasive fungal infection:focus on cutoff levels[J]. J Microbiol Immunol Infect,2015,48(4):351-361.
[16]	SHABAAN A E,ELBAZ L M,EL-EMSHATY W M,et al. Role of serum (1,3)-β-d-glucan assay in early diagnosis of invasive fungal infections in a neonatal intensive care unit[J]. J Pediatr(Rio J),2018,94(5):559-565.
[17]	OBAYASHI T,NEGISHI K,SUZUKI T,et al.Reappraisal of the Serum(1→3)-beta-D-glucan assay for the diagnosis of invasive fungal infections-a study based on autopsy cases from 6 years[J]. Clin Infect Dis,2008,46(12):1864-1870.
[18]	SMITH P B,BENJAMIN DK Jr,ALEXANDER B D,et al.Quantification of 1,3-beta-D-glucan levels in children:preliminary data for diagnostic use of the beta-glucan assay in a pediatric setting[J]. Clin Vaccine Immunol,2007,7(14):924-925.
[19]	GOUDJIL S,KONGOLO G,DUSOL L,et al.(1-3)-β-D-glucan levels in candidiasis infections in the critically ill neonate[J]. J Matern Fetal Neonatal Med,2012,26(1):44-48.
[20]	CALITRI C,CAVIGLIA I,CANGEMI G,et al.Performance of 1,3-β-D-glucan for diagnosing invasive fungal diseases in children[J]. Mycoses,2017,60(12):789-795.
[21]	HARON E,VARTIVARIAN S,ANAISSIE E,et al.Primary Candida pneumonia. Experience at a large cancer center and review of the literature[J]. Medicine(Baltimore),1993,72(3):137-142.
[22]	PAPPAS P G,KAUFFMAN C A,ANDES D R,et al.Clinical practice guidelines for the management of candidiasis:2009 update by the Infectious Diseases Society of America[J]. Clin Infect Dis,2009,48(5):503-535.
[23]	SU K C,CHOU K T,HSIAO Y H,et al.Measuring(1,3)-β-D-glucan in tracheal aspirate,bronchoalveolar lavage fluid,and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients:a prospective observational study[J]. BMC Infect Dis,2017,17(1):252.
[24]	SHI X Y,LIU Y,GU X M,et al.Diagnostic value of (1→3)-β-D-glucan in bronchoalveolar lavage fluid for invasive fungal disease:a meta-analysis[J]. Respir Medicine,2016,117:48-53.
[25]	URABE N,SAKAMOTO S,SANO G,et al.Usefulness of two aspergillus PCR assays and aspergillus galactomannan and β-d-glucan testing of bronchoalveolar lavage fluid for diagnosis of chronic pulmonary aspergillosis[J]. J Clin Microbiol,2017,55(6):1738-1746.
[26]	ROSE S R,VALLABHAJOSYULA S,VELEZ M G,et al.The utility of bronchoalveolar lavage beta-D-glucan testing for the diagnosis of invasive fungal infections[J]. J Infect,2014,69(3):278-283.
[27]	LYONS J L,THAKUR K T,LEE R,et al.Utility of measuring(1,3)-β-d-glucan in cerebrospinal fluid for diagnosis of fungal central nervous system infection[J]. J Clin Microbiol,2015,53(1):319-322.
[28]	BROWN G D,GORDON S.Immune recognition of fungal beta-glucans[J]. Cell Microbiol,2005,7(4):471-479.
[29]	LITVINTSEVA A P,LINDSLEY M D,GADE L,et al.Utility of(1-3)-β-D-glucan testing for diagnostics and monitoring response to treatment during the multistate outbreak of fungal meningitis and other infections[J]. Clin Infect Dis,2014,58(5):622-630.
[30]	ODABASI Z,PAETZNICK V L,RODRIGUEZ J R,et al.Differences in beta-glucan levels in culture supernatants of a variety of fungi[J]. Med Mycol,2006,44(3):267-272.
[31]	RHEIN J,BAHR N C,MORAWSKI B M,et al. Detection of high cerebrospinal fluid levels of (1→3)-β-d-glucan in cryptococcal meningitis[J]. pen Forum Infect Dis,2014,1(3):ofu105.
[32]	SCHELENZ S,BARNES R A,BARTON R C,et al.British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases[J]. Lancet Infect Dis,2015,15(4):461-474.
[33]	ODABASI Z,MATTIUZZI G,ESTEY E,et al.Beta-D-glucan as a diagnostic adjunct for invasive fungal infections:validation,cutoff development,and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome[J]. Clin Infect Dis,2004,39(2):199-205.
[34]	TISSOT F,LAMOTH F,HAUSER P M,et al.β-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis[J]. Am J Respir Crit Care Med,2013,188(9):1100-1109.
[35]	PAZOS C,PONTÓN J,DEL PALACIO A. Contribution of(1→3)-beta-D-glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients:a comparison with serial screening for circulating galactomannan[J]. J Clin Microbiol,2005,1(43):299-305.
[36]	ELLIS M,AL-RAMADI B,FINKELMAN M,et al.Assessment of the clinical utility of serial -D-glucan concentrations in patients with persistent neutropenic fever[J]. J Med Microbiol,2008,57(Pt 3):287-295.
[37]	GIACOBBE D R,MIKULSKA M,TUMBARELLO M,et al.Combined use of serum(1,3)-β-D-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units[J]. Crit Care,2017,21(1):176.
[38]	KANDA H,KUBO K,HAMASAKI K,et al.Influence of various hemodialysis membranes on the plasma (1→3)-β-D-glucan level[J]. Kidney Int,2001,60(1):319-323.
[39]	PICKERING J W,SANT H W,BOWLES C A,et al.Evaluation of a(1→3)-beta-D-glucan assay for diagnosis of invasive fungal infections[J]. J Clin Microbiol,2005,43(12):5957-5962.
[40]	LO CASCIO G,KONCAN R,STRINGARI G,et al.Interference of confounding factors on the use of(1,3)-beta-D-glucan in the diagnosis of invasive candidiasis in the intensive care unit[J]. Eur J Clin Microbiol Infect Dis,2015,34(2):357-365.
[41]	WASSER S P.Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides[J]. Appl Microbiol Biotechnol,2002,60(3):258-274.
[42]	ZHENG F,ZHA H,YANG D,et al.Diagnostic values and limitations of(1,3)-β-D-glucans and galactomannan assays for invasive fungal infection in patients admitted to pediatric intensive care unit[J]. Mycopathologia,2017,182(3-4):331-338.
[43]	HASHIMOTO N,MORI T,HASHIDA R,et al.False-positive serum(1,3)-β-D-glucan elevation due to intake of seaweed in a hematopoietic stem cell transplant recipient[J]. Transpl Infect Dis,2017,19(2):12653.
[44]	MENNINK-KERSTEN M,RUEGEBRINK D,VERWEIJ P E.Pseudomonas aeruginosa as a cause of 1,3-beta-D-glucan assay reactivity[J]. Clin Infect Dis,2008,46(12):1930-1931.
[45]	ALBERT O,TOUBAS D,STRADY C,et al.Reactivity of(1→3)-β-d-glucan assay in bacterial bloodstream infections[J]. Eur J Clin Microbiol Infect Dis,2011,30(11):1453-1460.
[46]	KONCAN R,FAVUZZI V,LIGOZZI M,et al.Cross-reactivity of Nocardia spp. in the fungal(1-3)-β-d-glucan assay performed on cerebral spinal fluid[J]. Diagn Microbiol Infect Dis,2015,81(2):94-95.
[47]	MARTY F M,LOWRY C M,LEMPITSKI S J,et al.Reactivity of(1→3)-beta-d-glucan assay with commonly used intravenous antimicrobials[J]. Antimicrob Agents Chemother,2006,50(10):3450-3453.
[48]	MENNINK-KERSTEN M A,WARRIS A,VERWEIJ P E. 1,3-Beta-D-glucan in patients receiving intravenous amoxicillin-clavulanic acid[J]. N Engl J Med,2006,354(26):2834-2835.
[49]	GUITARD J,TABONE M D,SENGHOR Y,et al.Detection of β-D-glucan for the diagnosis of invasive fungal infection in children with hematological malignancy[J]. J Infect,2016,73(6):607-615.