Research progress of pseudouridine as a biomarker of kidney disease and cancer

doi:10.3969/j.issn.1673-8640.2019.09.022

Abstract

Abstract:

Pseudouridine（PU） is the isomeride of uracil nucleoside,which is mainly produced by the metabolism of transfer RNA（tRNA）. PU can not be reused and is eliminated through urine directly. With further study,PU is getting more and more attention as a biomarker. This review describes the metabolic characteristics and determination methods of PU,evaluates the role of PU in the diagnosis and treatment of kidney diseases and cancers,and looks forward to the significance of PU on metabonomics.

Key words: Pseudouridine, Chronic kidney disease, Hepatocellular carcinoma, Lung cancer

CLC Number:

R392.9

CHEN Xu, FENG Juan, HU Xiaobo, WANG Changfu. Research progress of pseudouridine as a biomarker of kidney disease and cancer[J]. Laboratory Medicine, 2019, 34(9): 864-867.

Figures/Tables 1

References 33

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