Investigation on the significance of neutrophil gelatinase-associated lipocalin on early diagnosis of acute kidney injury after adult cardiac surgery

doi:10.3969/j.issn.1673-8640.2014.02.012

Abstract

Abstract:

Objective To investigate the early diagnosis significance of neutrophil gelatinase-associated lipocalin (NGAL) on acute kidney injury (AKI) in patients undergoing cardiac surgery. Methods Blood samples before and after surgery were collected from 62 patients undergoing cardiac surgery. The blood samples were collected before surgery and at 6, 24 and 48 h after surgery respectively. The serum creatinine (SCr) was detected by enzymatic method.AKI was defined as diagnosis standard at SCr≥26.5 μmol/L within 48 h.There were 23 AKI patients (AKI group) and 39 patients without AKI (non AKI group). Serum NGAL and serum cystatin C(Cys C) were detected by latex-enhanced immunoturbidimetry. Results Serum NGAL increased significantly at 6, 24, 48 h after surgery(P<0.01), while serum Cys C increased at 24 and 48 h after surgery in AKI group (P<0.01). There wasno statistical significance for NGAL in non AKI group before and at 6, 24 and 48 h after surgery(P>0.05).There was no statistical significance for CysC in non AKI group before and at 6 and 24 h after surgery(P>0.05).However, Cys C in non AKI group at 48 h after surgery increased (P<0.05). Conclusions Serum NGAL at 6 h after cardiac surgery are predictive for AKI, which is much earlier than Cys C and SCr. Serum NGAL can be used as early markers for AKI after cardiac surgery.

Key words: Neutrophil gelatinase-associated lipocalin, Acute kidney injury, Cardiac surgery

CLC Number:

R446.1

XU Lei, XU Xiaoping, YING Chunmei.. Investigation on the significance of neutrophil gelatinase-associated lipocalin on early diagnosis of acute kidney injury after adult cardiac surgery[J]. , 2014, 29(2): 139-142.

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