Research on the influence of rude rhubarb on serum IL-10 and IL-18 levels in patients with severe acute pancreatitis

doi:10.3969/j.issn.1673-8640.2013.07.005

Abstract

Abstract: Objective To research the influence of rude rhubarb on serum interleukin 10 (IL-10) and interleukin 18 (IL-18) levels in patients with severe acute pancreatitis (SAP). Methods SAP patients were classified into group A(22 patients) and group B (36 patients) randomly.The patients in group A were given comprehensive treatment.On the basis of comprehensive treatment,the patients in group B were given rude rhubarb by nasojejunal feeding. The serum levels of IL-10 and IL-18 in the 2 groups were detected by enzyme-linked immunosorbert assay (ELISA) at different intervals (0 d, 7 d and 14 d). The sera of healthy subjects were as controls. Results On 0 d, the serum levels of IL-18 in A and B groups were higher than those in the control group (P<0.01), and the serum levels of IL-10 in A and B groups were also higher than those in the control group (P<0.05). However, the serum levels of IL-18 and IL-10 between A and B groups had no statistical significance (P>0.05). On 7 d,the serum levels of IL-18 in A and B groups decreased compared with those on 0 d, especially in group B, and there were statistical significances between A and B groups (P<0.01). On 7 d,the serum levels of IL-10 in A group didn′t change obviously compared with those on 0 d, but the serum levels of IL-10 in B group significantly increased compared with those on 0 d (P<0.01) .On 14 d, the serum levels of IL-18 in A and B groups decreased compared with those on 7 d with no statistical significance (P>0.05), but the levels of IL-18 between A and B groups showed significant differences(P<0.01). On 14 d, the serum levels of IL-10 in A and B groups increased compared with those on 7 d with no statistical significance (P>0.05), but the levels of IL-10 between A and B groups showed significant differences (P<0.05). The total effective rate in B group after administration of rude rhubarb was higher than that in A group (P<0.05). IL-18 and blood amylases were positively correlated (r_A=0.55,P<0.05;r_B=0.81,P<0.01), and IL-18 and urine amylases were positively correlated (r_A=0.51,P<0.05;r_B=0.79,P<0.01). There was negative correlation between IL-10 and blood amylases(r_A=-0.46,P<0.05;r_B=-0.72,P<0.01), and urine amylases(r_A=-0.44,P<0.05;r_B=-0.63,P<0.01)in A and B groups. Conclusions The administration of rude rhubarb can effectively reverse SAP by regulating the serum levels of IL-10 and IL-18.

Key words: Interleukin 10, Interleukin 8, Rude rhubarb, Severe acute pancreatitis, Nasojejunal tube

CLC Number:

R446.62

YU Xiuwen,WU Sufen. Research on the influence of rude rhubarb on serum IL-10 and IL-18 levels in patients with severe acute pancreatitis[J]. , 2013, 28(7): 581-584.

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