Abstract:

Objective To investigate the correlation between the level of interleukin 2 receptor（IL-2R）,interleukin（IL）-6,IL-8 and IL-10 before treatment and the postoperative 30 d prognosis after hip joint fracture in elderly patients. Methods A total of 179 elderly patients with hip joint fracture were enrolled,and the preoperative levels of serum IL-2R,IL-6,IL-8 and IL-10 were determined and followed up for 30 d. Kaplan-Meier curve and Log-rank test were used to analyze the survival rate of elderly patients with hip joint fracture at postoperative 30 d. Cox regression analysis was used to evaluate the risk factors of death for 30 d after hip joint fracture. Results Among the 179 elderly patients with hip joint fracture,18 died during the 30 d after operation,the mortality rate was 10.06%. The levels of IL-2R,IL-6 and IL-8 in death group were higher than those in survival group（P<0.05）. There was no statistical significance in IL-10 level between the 2 groups（P>0.05）. Multivariate Cox regression analysis showed that the increase of IL-2R,IL-6 and IL-8 before operation were risk factors for 30 d death in elderly patients with hip joint fracture [odds ratios（OR） were 1.020,1.008 and 1.004,95% confidence intervals（CI） were 1.010-1.031,1.002-1.015 and 1.000-1.007,respectively,P<0.001]. According to the medians of preoperative serum IL-2R,IL-6 and IL-8 levels of elderly patients with hip joint fracture,Kaplan-Meier survival curve analysis results showed that the 30 d survival rates of high IL-2R,high IL-6 and high IL-8 groups were lower than those of low IL-2R,low IL-6 and low IL-8 groups（Log-rank χ²=7.54,6.03 and 8.22,P<0.05）. Conclusions The levels of IL-2R,IL-6 and IL-8 before operation can be used as indicators of postoperative evaluation,and the prognosis of elderly hip joint fracture patients with high preoperative levels of IL-2R,IL-6 and IL-8 is poor.

Key words: Interleukin 2 receptor, Interleukin 6, Interleukin 8, Interleukin 10, Hip joint fracture, Elderly