The dynamic observation of vascular endothelial growth factor in type 2 diabetes mellitus patients during glucose tolerance test

doi:10.3969/j.issn.1673-8640.2013.07.004

Abstract

Abstract: Objective To study the dynamic change of vascular endothelial growth factor (VEGF) in type 2 diabetes mellitus (T2DM) patients during oral glucose (GLU) tolerance test(OGTT). Methods OGTT was performed in T2DM patients and healthy controls. The GLU, insulin (INS), VEGF concentrations in different times were determined. The secretion regularity of VEGF and INS was analyzed. Results VEGF secretion did not change significantly in control group for OGTT(P>0.05). The VEGF in T2DM group at 30, 60 and 120 min decreased more significantly comparing to the VEGF at fasting (P<0.05 or 0.01). The VEGF at 180 min and fasting had no significant difference (P>0.05). The INS at 30, 60, 120 and 180 min in T2DM group had significant difference with that at fasting (P<0.05). The highest value of INS in control group was higher than that in T2DM group (P<0.05). Conclusions The cell disfunction of beta cells, VEGF-secreting cells and other cells exists in T2DM.

Key words: Vascular endothelial growth factor, Insulin, Cell function, Type 2 diabetes mellitus

CLC Number:

R446.62

ZHANG Li,GE Caibao,HUANG Zhongwei. The dynamic observation of vascular endothelial growth factor in type 2 diabetes mellitus patients during glucose tolerance test[J]. , 2013, 28(7): 577-580.

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