Abstract:

Objective To study the changes of peripheral blood CD4⁺CD25^highFoxP3⁺ regulatory T lymphocytes (Treg) and interferon gamma (IFN-γ), interleukin 10 (IL-10) levels of patients with lymph tuberculosis and their clinical significance. Methods The levels of peripheral blood CD4⁺CD25^highFoxP3⁺ Treg, IFN- γ and IL-10 of 100 lymph tuberculosis patients and 30 healthy subjects were determined by flow cytometry. Results Compared with the healthy controls, the levels of peripheral blood CD4⁺CD25^highFoxP3⁺ Treg and IL-10 levels in lymph tuberculosis group increased with statistical significance (P<0.05), while IFN-γ level decreased (P<0.05). Among the caseous, proliferation and mixed types of lymph tuberculosis, there was no significant difference (P>0.05). Conclusions Cellular immune function is significantly abnormal in patients with lymph tuberculosis. CD4⁺CD25^highFoxP3⁺ Treg, IFN- γ and IL-10 play important roles in the onset process of lymph tuberculosis.

Key words: CD4+CD25highFoxP3+ regulatory T lymphocyte, Interferon gamma, Interleukin 10, Lymph tuberculosis