Abstract: Objective　To study the status of infection and the genotype distribution of human papillomavirus （HPV） among women in Sanya area. Methods　A total of 2 302 outpatient women in Sanya area from February 2009 to April 2011 were enrolled and determined for 21 HPV genotypes by DNA flow-through hybridization technique. Results　Among 2 302 cases, 562 cases were HPV positive, and the total positive rate was 24.41%. The highest infection rate （36.00%） was found in the age group of ≤20 years old, and the positive rate of HPV decreased with age. The total multiple infection rate was 58.54%. Among them, the double infection was common. The detection rate of detecting HPV genotypes were HPV16（21.06%）, HPV6（14.16%）, HPV58（13.02%）, HPV18（9.63%）, HPV52（9.29%）, HPV11（6.80%）, HPV31（6.34%）, HPVCP8304（5.21%）, HPV42（3.06%）, HPV53（2.04%）, HPV51（1.70%）, HPV66（1.70%）, HPV68（1.02%）, HPV33（0.91%）, HPV39（0.68%）, HPV44（0.68%）, HPV35（0.57%）, HPV45（0.57%）, HPV56（0.57%）, HPV43（0.57%） and HPV59（0.45%）. Conclusions　The prevalence of HPV infection and multiple infection are common in Sanya area. The most common high-risk genotypes are HPV 16, 58, 18, 52 and 31. The distributions have their own area character.

Key words: Human papillomavirus, Cervical tumor, Epidemiology