Abstract: Objective　To analyze the determination results of antibody to hepatitis C virus（HCV）in patients and healthy subjects， understand the infection state of hepatitis C in Fuzhou， and to provide reference for clinical treatment. Methods　The antibodies to HCV in 31 551 patients and healthy subjects were determined by chemiluminescence immunoassay. Results　In all 31 551 patients and healthy subjects，the total positive rate for antibody to HCV was 1.15%（363/31 551）.The positive rate of males was 1.33％，and the positive rate of females was 0.97％.The highest in all age groups was the 61-70 years old group， which the positive rate was 1.83%.In the all antibody to HCV positive patients，patients with the S/CO ratio of 1.01-5.00 and >20.01 accounted for 47.38% and 33.88%，respectively.Among 319 positive patients with retrospective clinical data，patients with benign liver diseases，other benign diseases， liver cancer and other cancers accounted for 7.21%，83.39%，6.27% and 16.93%，respectively. Patients with the history of blood transfusion，surgery，hemodialysis，hepatitis B virus infection，drug abuse and mother-to-child transmission accounted for 4.39%，34.80%，18.18%，19.44%，0.63% and 0.63%，respectively. Conclusions　The situation of HCV infection is complicated.Besides blood transmission，other routes of transmission cannot be eglected.Subjects with no clinical symptom must be routinely detected for the antibody to HCV.

Key words: Hepatitis C virus, Antibody, Chemiluminescence immunoassay