Abstract:

Objective To analyze the relationship between different antibody subtypes of Helicobacter pylori （Hp） infection and the pathological characteristics of the stomach，as well as the correlations between serum pepsinogen （PG） Ⅱ，the ratio of pepsinogen Ⅰ-to-pepsinogen Ⅱ（PGⅠ/PGⅡ） and gastrin 17 （G-17） in patients with chronic gastritis and type Ⅰ Hp infection，inflammatory activity，atrophy degree and intestinal metaplasia degree. Methods A retrospective analysis was conducted on 236 patients with benign gastric diseases admitted to the Gastroenterology Department of Zengcheng Branch of Nanfang Hospital of Southern Medical University from July 2022 to February 2024. Among them，78 cases were positive for type Ⅰ Hp antibodies （type Ⅰ Hp infection group），47 cases were positive for type Ⅱ Hp antibodies （type Ⅱ Hp infection group），and 111 cases were negative for Hp antibodies （control group）. All the clinical data and relevant laboratory determination results were collected，and the differences among the groups were compared. By Spearman correlation analysis，the correlations between PG Ⅱ，PGR，G-17 and the activity of gastric inflammation，degree of atrophy （OLGA staging），degree of intestinal metaplasia （OLGIM staging），type Ⅰ Hp infection were evaluated. Results The type Ⅰ Hp infection group was positively correlated with the activity of gastric inflammation，OLGA stage and OLGIM stage （P<0.05）. When the activity of gastric inflammation was grade 3 （+++），the infection rate of the type Ⅰ Hp infection group was 4.9 times that of the type Ⅱ Hp infection group （P<0.05）. When the OLGA stage was stage Ⅲ，the infection rate of the type Ⅰ Hp infection group was 2.1 times that of the type Ⅱ Hp infection group （P<0.05）. When the OLGIM stage was stage Ⅲ，the infection rate of the type Ⅰ Hp infection group was 2.6 times than that of the type Ⅱ Hp infection group （P<0.05）. There was statistical significance in serum PGⅡ，PGR and G-17 levels among control group，type Ⅰ Hp infection group and type Ⅱ Hp infection group （P<0.05）. In patients with chronic gastritis，serum PGⅡ was positively correlated with type Ⅰ Hp infection，the activity of gastric inflammation，the degree of atrophy and the degree of intestinal metaplasia （P<0.05）. Serum PGR was negatively correlated with type Ⅰ Hp infection，the activity of inflammation，OLGA stage and OLGIM stage （P<0.05）. Serum G-17 level was positively correlated with type Ⅰ Hp infection and the activity of gastric inflammation and OLGIM stage（P<0.05）. Conclusions Type Ⅰ Hp infection has an influence on the development of benign gastric diseases，the levels of PGⅡ，PGR and G-17 in chronic gastritis patients are correlated with type Ⅰ Hp infection and gastric pathological changes，such as inflammatory activity，atrophy and intestinal metaplasia.

Key words: Helicobacter pylori, Antibody typing, Chronic gastritis