Abstract:

Objective To evaluate the role of latex immunoturbidimetric assay in the determination of serum Helicobacter pylori （HP） antibody. Methods A total of 120 patients with suspected HP infection who underwent gastroscopy and healthy subjects were enrolled,and Hp was determined by silver staining,latex immunoturbidimetric assay and colloidal gold rapid assay. Results Using silver staining as gold standard,the sensitivity,specificity,negative predictive value and positive predictive value of latex immunoturbidimetric assay were 93.3%,96.7%,93.6%,96.6% and 95.0%,respectively. The sensitivity and diagnostic consistency rate were higher than those of colloidal gold rapid assay（P<0.01）. Conclusions Latex immunoturbidimetric assay is simple, rapid,sensitive,specific,reproducible,accurate for the determination of serum HP antibody,especially for large-scale screening of susceptible population.

Key words: Helicobacter pylori, Latex immunoturbidimetric assay, Antibody