Abstract:

Objective To investigate the roles of fecal calprotectin（FC），C-reactive protein（CRP），erythrocyte sedimentation rate（ESR），interleukin-6（IL-6），tumor necrosis factor（TNF）-α and heparin-binding protein（HBP） in the diagnosis of colonic mucosal lesions in children with Crohn's disease（CD）. Methods Totally，85 children with CD at Ruijin Hospital of Shanghai Jiao Tong University School of Medicine from January 2021 to January 2023 were enrolled and classified into mucosal healing group and mucosal lesion group according to the simple endoscopic score for Crohn's disease（SES-CD），and 19 patients with functional gastrointestinal disease were enrolled as control group. FC，CRP，ESR，IL-6，TNF-α and HBP were determined. Results The levels of FC，IL-6 and TNF-α in mucosal lesion group were higher than those in control group（P<0.05）. There was statistical significance in FC，CRP，ESR，IL-6 and HBP levels between mucosal lesion group and mucosal healing group（P<0.05）. FC，CRP，ESR，IL-6 were positively correlated with SES-CD（P<0.05）. The sensitivity and specificity of FC in determining mucosal healing and mucosal lesion were 84.2% and 98.5%，respectively. Conclusions The levels of FC，CRP，ESR，IL-6 and HBP are related to mucosal healing and lesion status and prognosis of children with CD.

Key words: Fecal calprotectin, Crohn's disease, Children