Abstract:

Objective To investigate the clinical application roles of influenza A virus（FluA） antigen,FluA nucleic acid and Filmarray rapid pathogen detection technologies for detecting FluA. Methods The patients with suspected FluA infection in Xijing Hospital from October 2016 to January 2019 were enrolled for the detections of FluA nucleic acid and antigen. The results were analyzed comparatively. Filmarray rapid pathogen detection was used as well. Results The positive rate of FluA antigen detection was 9.56%,and the positive rate of FluA nucleic acid detection was 27.29%. The period from December to February was the outbreak season,and the positive rate of FluA antigen detection in this period was 10.95%,and the positive rate of FluA nucleic acid detection in this period was 27.71%. Infants <5 years old,adolescents around 20 years old and elders >90 years old were susceptible subjects. There was no statistical significance in FluA nucleic acid detection between males and females（P<0.05）. Using Filmarray rapid pathogen detection technology,170 positive specimens were detected,and 207 positive results were obtained,some of which included multiple infection resulted from different respiratory pathogens. Conclusions FluA antigen and nucleic acid detections could clarify the infection. Filmarray rapid pathogen detection technology could serve the diagnosis of infectious diseases and is of significance for the diagnosis and treatment of clinical respiratory tract infection.

Key words: Influenza A virus, Respiratory tract infection, Antigen, Nucleic acid, Filmarray rapid pathogen detection technology