Abstract:

Objective To understand the status of corona virus disease 2019（COVID-19） patients with respiratory tract pathogen mixed infection. Methods Totally,500 patients with COVID-19 were classified into 4 groups,including light group（205 cases）,common group（195 cases）,severe group（65 cases） and critical group（35 cases）. The IgM antibodies of 8 common respiratory tract pathogens in patients with COVID-19 were determined by indirect immunofluorescence,which included influenza A,influenza B,parainfluenza virus,respiratory syncytial virus,adenovirus,Mycoplasma pneumoniae,Chlamydia pneumoniae and Legionella pneumophila IgM. Results The respiratory tract pathogen mixed infection accounted for 9.76%,10.26%,18.46% and 28.57% in light group（20 cases）,common group（20 cases）,severe group（12 cases） and critical group（10 cases）,respectively（P<0.05）. The respiratory tract pathogen mixed infection totally accounted for 12.4%（62 cases）,of which 26 cases had multiple infections,accounting for 5.2%,showing an increasing trend（P<0.05）. Conclusions There are mixed infection in patients with COVID-19. The rate of mixed infection and the severity of COVID-19 are increasing. In the clinical diagnosis and treatment process,it should pay attention to the combined usage of drugs to improve the cure rate.

Key words: Corona virus disease 2019, Respiratory tract pathogen, Mixed infection