Abstract:

Objective To evaluate the diagnostic value of red blood cell distribution width（RDW） and monocyte to lymphocyte ratio（MLR） in ankylosing spondylitis（AS）. Methods A total of 131 AS patients,137 other rheumatic diseases and 135 healthy subjects were enrolled from the First Hospital of Jilin University. The correlations of RDW and MLR with the clinical indexes of AS were evaluated. Results RDW and MLR were higher than those in healthy subjects（P<0.05）. There was statistical significance between RDW and MLR in the positive and negative patients defined by high-sensitivity C-reactive protein（hs-CRP） and erythrocyte sedimentation rate（ESR）（P<0.05）. There was statistical significance in MLR between IgG, IgA,IgM abnormal and normal patients（P<0.05）. RDW was positively correlated with ESR and hs-CRP,and the correlation coefficients（r） were 0.277 and 0.225, respectively. MLR was positively correlated with ESR,hs-CRP,IgG,IgA and complement 3（C3）, and the r were 0.358,0.399,0.214,0.183 and 0.241,respectively. Conclusions Both RDW and MLR may play roles for AS diagnosis and disease observation.

Key words: Red blood cell distribution width, Monocyte to lymphocyte ratio, Ankylosing spondylitis