Change of red blood cell distribution width and its significance in patients with primary biliary cirrhosis

doi:10.3969/j.issn.1673-8640.2015.09.001

Abstract

Abstract: Objective

To investigate the clinical significance of red blood cell distribution width (RDW) in patients with primary biliary cirrhosis (PBC).

Methods

A total of 98 patients with PBC and 88 healthy subjects were enrolled, and their data were analyzed retrospectively. The change of RDW in PBC patients and the relationships with total bilirubin(TBil), creatinine(Cr), albumin(Alb), platelet(PLT), gamma glutamyltransferase(GGT), alkaline phosphatase(ALP) and Mayo risk score were analyzed.

Results

RDW in PBC group (14.9%±2.8%) was higher than that in healthy control group (12.3%±0.4%, P<0.05), and there was statistical significance for TBil, Cr, PLT, Alb, GGT and ALP between the 2 groups (P<0.05). RDW was positively correlated with TBil, ALP and Mayo risk score (r=0.61, 0.46 and 0.51, P<0.05), and was negatively correlated with Alb and PLT (r=-0.69 and -0.46, P<0.05).

Conclusions

The increasing of RDW is a potential index for the severity of PBC.

Key words: Primary biliary cirrhosis, Red blood cell distribution width

CLC Number:

R446.11

FU Haitao, YANG Min, HUANG Fenglou, LIANG Yan, ZHONG Renqian. Change of red blood cell distribution width and its significance in patients with primary biliary cirrhosis[J]. Laboratory Medicine, 2015, 30(9): 871-873.

Figures/Tables 2

References 13

[1]	YESIL A, SENATES E, BAYOGˇLU IV, et al. Red cell distribution width: a novel marker of activity in inflammatory bowel disease[J]. Gut Liver, 2011,5(4):460-467.
[2]	SONG CS, PARK DI, YOON MY, et al.Association between red cell distribution width and disease activity in patients with inflammatory bowel disease[J]. Dig Dis Sci, 2012,57(4):1033-1038.
[3]	LEE WS, KIM TY.Relation between red blood cell distribution width and inflammatory biomarkers in rheumatoid arthritis[J]. Arch Pathol Lab Med, 2010,134(4):505-506.
[4]	HU ZD, CHEN Y, ZHANG L, et al.Red blood cell distribution width is a potential index to assess the disease activity of systemic lupus erythematosus[J]. Clin Chim Acta, 2013,425:202-205.
[5]	VAYÁ A, ALIS R, HERNÁNDEZ JL, et al. RDW in patients with systemic lupus erythematosus. Influence of anaemia and inflammatory markers[J]. Clin Hemorheol Microcirc, 2013,54(3):333-339.
[6]	BOWLUS CL, GERSHWIN ME.The diagnosis of primary biliary cirrhosis[J]. Autoimmun Rev, 2014,13(4-5):441-444.
[7]	梁艳, 杨再兴, 曾贤铭,等. 原发性胆汁性肝硬化患者外周血APRIL基因表达水平初探[J]. 临床检验杂志, 2007,25(1):51-53.
[8]	HEATHCOTE EJ.Management of primary biliary cirrhosis. The American Association for the Study of Liver Diseases practice guidelines[J]. Hepatology, 2000,31(4):1005-1013.
[9]	SELMI C, BOWLUS CL, GERSHWIN ME, et al.Primary biliary cirrhosis[J]. Lancet, 2011,377(9777):1600-1609.
[10]	LIPPI G, TARGHER G, MONTAGNANA M, et al.Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients[J]. Arch Pathol Lab Med, 2009,133(4):628-632.
[11]	PATEL KV, SEMBA RD, FERRUCCI L, et al.Red cell distribution width and mortality in older adults: a meta-analysis[J]. J Gerontol A Biol Sci Med Sci, 2010,65(3):258-265.
[12]	HALIFEOGLU I, GUR B, AYDIN S, et al.Plasma trace elements, vitamin B12, folate, and homocysteine levels in cirrhotic patients compared to healthy controls[J]. Biochemistry (Mosc), 2004,69(6):693-696.
[13]	CÁRDENAS A, GINÈS P. Portal hypertension[J]. Curr Opin Gastroenterol, 2009,25(3):195-201.

组别	例数	TBil(μmol/L)	Cr(μmol/L)	PT(s)	PLT(×10⁹/L)
正常对照组	88	12.0(8.0,15.0)	65.0(63.0,72.7)	-	243(204.0,272.7)
PBC组	98	18.0(12.3,43.0)	54.0(46.0,65.0)	14.4±2.3	122.0(81.7,188.0)
P值		<0.05	<0.05	-	<0.05
组别	例数	Alb(g/L)	GGT(U/L)	RDW(%)	ALP(U/L)
正常对照组	88	47.0(45.0,48.0)	17.0(12.7,23.0)	12.4(12.0,12.7)	62.0(50.0,78.0)
PBC组	98	40.0(34.0,46.0)	111.5(49.0,191.0)	14.1(12.8,16.2)	179.0(122.5,274.5)
P值		<0.05	<0.05	<0.05	<0.05

组别	例数	TBil(μmol/L)	Cr(μmol/L)	PT(s)	PLT(×10⁹/L)
正常对照组	88	12.0(8.0,15.0)	65.0(63.0,72.7)	-	243(204.0,272.7)
PBC组	98	18.0(12.3,43.0)	54.0(46.0,65.0)	14.4±2.3	122.0(81.7,188.0)
P值		<0.05	<0.05	-	<0.05
组别	例数	Alb(g/L)	GGT(U/L)	RDW(%)	ALP(U/L)
正常对照组	88	47.0(45.0,48.0)	17.0(12.7,23.0)	12.4(12.0,12.7)	62.0(50.0,78.0)
PBC组	98	40.0(34.0,46.0)	111.5(49.0,191.0)	14.1(12.8,16.2)	179.0(122.5,274.5)
P值		<0.05	<0.05	<0.05	<0.05

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