Efficiency of red blood cell parameter formulas for the differential diagnosis of iron-deficiency anemia and beta-thalassemia trait in children

doi:10.3969/j.issn.1673-8640.2018.10.009

Abstract

Abstract:

Objective To evaluate the efficiency of 8 red blood cell（RBC） parameter formulas for the differential diagnosis of iron-deficiency anemia（IDA） and beta-thalassemia trait（β-TT） in children. Methods A total of 149 patients with IDA and 146 patients with β-TT were enrolled. Their RBC parameters were determined. Totally,8 foreign common RBC parameter formulas（F1-F8） were used. Their sensitivities（SEN）,specificities（SPE）,positive predictive values（PPV）,negative predictive values（NPV）,Youden indices（YI）,positive likelihood ratios（+LR） and negative likelihood ratios（-LR） were evaluated. Receiver operating characteristic（ROC） curves were constructed,and the areas under curves（AUC） were calculated. Results The efficiencies of F5,F4 and F2 for the differential diagnosis of IDA and β-TT were high,and the AUC were 0.916,0.889 and 0.889,respectively,which were higher than those of the other 5 formulas. The efficiency of F5 was the highest,and the SEN and SPE were 87.14% and 88.41%,respectively. Conclusions F5,F4 and F2 show high efficiencies for the differential diagnosis of IDA and β-TT,especially for F5,which can be used for pediatric clinicians in Huizhou.

Key words: Red blood cell, Parameter formula, Iron-deficiency anemia, Beta-thalassemia trait, Children

CLC Number:

R446.1

HE Hailin, CHEN Jianhong, ZHONG Zeyan, YANG Kunxiang, GUAN Zhiyang, ZHONG Guoxing, DONG Hui. Efficiency of red blood cell parameter formulas for the differential diagnosis of iron-deficiency anemia and beta-thalassemia trait in children[J]. Laboratory Medicine, 2018, 33(10): 913-915.

Figures/Tables 3

References 13

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组别	RBC（×10¹²/L）	Hb（g/L）	MCV（fL）	MCH（pg）	MCHC（g/L）	RDW （%）
β-TT组	5.54±0.58^*	103.8±11.1^*	60.14±6.38^*	18.90±2.07^*	314.2±22.7^*	17.42±2.85^*
IDA组	4.69±0.50	111.3±14.6	72.60±7.58	24.10±3.33	331.7±20.7	14.48±2.32

组别	RBC（×10¹²/L）	Hb（g/L）	MCV（fL）	MCH（pg）	MCHC（g/L）	RDW （%）
β-TT组	5.54±0.58^*	103.8±11.1^*	60.14±6.38^*	18.90±2.07^*	314.2±22.7^*	17.42±2.85^*
IDA组	4.69±0.50	111.3±14.6	72.60±7.58	24.10±3.33	331.7±20.7	14.48±2.32

公式	文献界值	诊断界值^*	SEN（%）	SPE（%）	PPV（%）	NPV（%）	YI（%）	+LR	-LR	AUC
F1	≤1 530	≤935	91.43	71.01	76.20	89.10	0.62	3.15	0.12	0.860
F2	≤13.0	≤12.3	85.70	86.96	76.20	85.70	0.73	6.57	0.16	0.889
F3	≤3.80	≤3.86	77.14	84.06	83.10	78.40	0.61	4.84	0.27	0.851
F4	≤15.0	≤12.3	87.14	86.96	87.10	87.00	0.74	6.68	0.15	0.889
F5	≤27.00	≤26.76	87.14	88.41	88.40	87.10	0.76	7.52	0.15	0.916
F6	>44.76	>79.52	94.29	69.57	75.90	92.30	0.64	3.10	0.08	0.862
F7	≤72.00	≤57.62	73.86	88.41	86.40	76.20	0.61	6.28	0.31	0.847
F8	>23.85	>24.07	81.43	82.61	82.60	81.40	0.64	4.68	0.22	0.858

公式	文献界值	诊断界值^*	SEN（%）	SPE（%）	PPV（%）	NPV（%）	YI（%）	+LR	-LR	AUC
F1	≤1 530	≤935	91.43	71.01	76.20	89.10	0.62	3.15	0.12	0.860
F2	≤13.0	≤12.3	85.70	86.96	76.20	85.70	0.73	6.57	0.16	0.889
F3	≤3.80	≤3.86	77.14	84.06	83.10	78.40	0.61	4.84	0.27	0.851
F4	≤15.0	≤12.3	87.14	86.96	87.10	87.00	0.74	6.68	0.15	0.889
F5	≤27.00	≤26.76	87.14	88.41	88.40	87.10	0.76	7.52	0.15	0.916
F6	>44.76	>79.52	94.29	69.57	75.90	92.30	0.64	3.10	0.08	0.862
F7	≤72.00	≤57.62	73.86	88.41	86.40	76.20	0.61	6.28	0.31	0.847
F8	>23.85	>24.07	81.43	82.61	82.60	81.40	0.64	4.68	0.22	0.858

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