Abstract:

Objective To study the pathogenic characteristics of hand-foot-mouth disease in Tangxian of Baoding from 2012 to 2015,and to provide a reference for the prevention and controlling of hand-foot-mouth disease. Methods Fluorescence reverse transcription polymerase chain reaction（PCR） was used to determine throat specimens of 1 652 hand-foot-mouth disease suspected cases for enterovirus,enterovirus 71（EV71） and coxsackievirus A16（CA16）. Results Of the 1 652 hand-foot-mouth disease suspected cases,there were 511 positive cases for enterovirus. The positive cases for EV71,CA16 and other enteroviruses accounted for 31.31%,21.72% and 46.97%,respectively. In 2012,the primary pathogen causing hand-foot-mouth disease was EV71,but other enteroviruses became dominant pathogens for hand-foot-mouth disease from 2013 to 2015. The positive cases were determined all year round and distributed seasonally,with a peak appearing from May to August. Hand-foot-mouth disease changed its pathogenic constitution in different seasons. The main pathogens were other enteroviruses from January to June. The peak of EV71 appeared from July to September. CA16 became dominant pathogen from October to December. A majority of positive cases were children < 5 years old. EV71 was a superior epidemiological enterovirus for severe hand-foot-mouth disease. Conclusions The pathogenic monitoring of hand-foot-mouth disease needs be enhanced. The comprehensive controlling measures should be taken in key population from May to August,in order to prevent form hand-foot-mouth disease outbreak and spreading.

Key words: Pathogen, Enterovirus, Hand-foot-mouth disease