Abstract:

Objective To evaluate the incidence,maternal-neonatal transmission and genotype of syphilis in pregnant women from Zhabei District,and to investigate the influence of genotype change and specimen on determination results. Methods A total of 3 022 pregnant women were enrolled for syphilis screening. The specimens were collected from whole blood,plasma,ear lobe blood and skin of syphilis-positive patients for genotype determination. Clinical data were collected to evaluate incidence,maternal-neonatal transmission and social factors. Results A total of 41 pregnant women were positive in syphilis screening,and the positive rate was 1.32%. The proportion of maternal-neonatal transmission accounted for 43.9%（18/41）. The predominant type was 14d/f （80.9%,17/21）,followed by 15d/f（4.7%,1/21）,13a/f（4.7%,1/21）,13d/f（4.7%,1/21） and 9o/c（4.7%,1/21）. Genotyping efficiency of skin was the highest,and that of ear lobe blood was lower than that of skin,which were higher than those of whole blood and plasma. Conclusions The incidence of syphilis in pregnant women in Zhabei District is higher than that in Shanghai,and the kinds of genotypes are various. Ear lobe blood is a good choice of specimen for genotyping.

Key words: Treponema pallidum, Genotype, Maternal-neonatal transmission, Ear lobe blood