Strategies for syphilis serological determination

doi:10.3969/j.issn.1673-8640.2018.08.017

Abstract

Abstract:

Objective To investigate the roles of tolulized red unheated serum test（TRUST）,Treponema pallidum particle agglutination assay（TPPA）and chemiluminescence immunoassay（CLIA）for syphilis serological determination,and to formulate reasonable determination strategies.Methods The results of syphilis determination in 11 034 patients（excluding revisits） were analyzed retrospectively.Results The results of TPPA and CLIA had statistical significance for Treponema pallidumdetermination（P<0.01）. The specificities of the 3 methods were high,TPPA and CLIA had high sensitivities,and the sensitivity of TRUST was low.Conclusions The 3 methods have their advantages and disadvantages. Different determination strategies should be chosen according to different purposes.

Key words: Syphilis, Tolulized red unheated serum test, Treponema pallidum particle agglutination, Chemiluminescence immunoassay

CLC Number:

R446.1

WANG Qin. Strategies for syphilis serological determination[J]. Laboratory Medicine, 2018, 33(8): 749-751.

CLIA	TPPA		合计
CLIA	+	-	合计
+	718	46	764
-	12	10 258	10 270
合计	730	10 304	11 034

CLIA	TPPA		合计
CLIA	+	-	合计
+	718	46	764
-	12	10 258	10 270
合计	730	10 304	11 034

方法	敏感性	特异性	阳性预测值	阴性预测值
CLIA	99.20	99.84	97.91	99.94
TPPA	96.02	99.94	99.18	99.71
TRUST	62.33	99.90	97.92	97.31

方法	敏感性	特异性	阳性预测值	阴性预测值
CLIA	99.20	99.84	97.91	99.94
TPPA	96.02	99.94	99.18	99.71
TRUST	62.33	99.90	97.92	97.31

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Strategies for syphilis serological determination

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