Expression of Fas in peritoneal fluid mononuclear cells among endometriosis patients and its significance

doi:10.3969/j.issn.1673-8640.2015.05.011

Abstract

Abstract: Objective To investigate the relationship of Fas expression in peritoneal fluid mononuclear cells and endometriosis. Methods A total of 55 patients with histopathologically diagnosed endometriosis after operation were enrolled as endometriosis group, and 52 patients without endometriosis were enrolled as control group. The peritoneal fluid mononuclear cells were isolated, the expression levels of Fas mRNA were determined by reverse transcriptase-polymerase chain reaction(RT-PCR), and the percentage of Fas expression cells were quantitatively detected by flow cytometry. Results Fas mRNA and the percentage of Fas expression cells were significantly higher in endometriosis group than those in control group(P<0.05). There was no statistical significance between stage Ⅰ-Ⅱand stage Ⅲ-Ⅳ(P>0.05). Conclusions The abnormal Fas expression in peritoneal fluid mononuclear cells may play an important role in endometriosis.

Key words: Fas, Mononuclear cell, Peritoneal fluid, Endometriosis

CLC Number:

R446.1

LIU Hongzheng, WANG Yuliang. Expression of Fas in peritoneal fluid mononuclear cells among endometriosis patients and its significance[J]. Laboratory Medicine, 2015, 30(5): 454-456.

Figures/Tables 1

References 12

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组别	例数	Fas mRNA	Fas表达细胞(%)
子宫内膜异位症组	55	1.5±0.7^*	19.10±3.90^*
Ⅰ~Ⅱ期	38	1.2±0.6	17.83±1.45
Ⅲ~Ⅳ期	17	1.4±0.7	20.04±4.81
对照组	52	1.1±0.4	16.38±1.17

组别	例数	Fas mRNA	Fas表达细胞(%)
子宫内膜异位症组	55	1.5±0.7^*	19.10±3.90^*
Ⅰ~Ⅱ期	38	1.2±0.6	17.83±1.45
Ⅲ~Ⅳ期	17	1.4±0.7	20.04±4.81
对照组	52	1.1±0.4	16.38±1.17

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