Abstract: Objective To observe the bactericidal and bacteriostatic effects of Schisandra chinensis fruit against Acinetobacter baumannii which was resistant to cefoperazone-sulbactam or non-resistant to cefoperazone-sulbactam. Methods The extract of Schisandra chinensis fruit was prepared, bacteriostatic and bactericidal test in vitro by tube double dilution method was performed to observe their minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) to Acinetobacter baumannii. Results The MIC50 of Schisandra chinensis fruit against Acinetobacter baumannii resistant to cefoperazone-sulbactam or non-resistant to cefoperazone-sulbactam were 15.6 and 7.8 mg/mL, and on this drug concentration, the inhibitory rate against non-resistant to cefoperazone-sulbactam Acinetobacter baumannii was higher than that against resistant to cefoperazone-sulbactam (χ²=4.26 and 3.98, P<0.05). When the drug concentration reached to 31.3mg/mL, the inhibitory rates were all 100%. The MBC50 of Schisandra chinensis fruit against Acinetobacter baumannii which was resistant tocefoperazone-sulbactam or non-resistant to cefoperazone-sulbactam were 31.3 mg/mL, and the bactericidal rate had no statistical significance (χ²=0.74, P>0.05). Conclusions The Schisandra chinensis fruit has certain bactericidal and bacteriostatic effects on Acinetobacter baumannii which was resistant to cefoperazone-sulbactam or non-resistant to cefoperazone-sulbactam in vitro, and the MIC against Acinetobacter baumannii is a little higher. It suggests that Schisandra chinensis fruit could be used for the clinical treatment of Acinetobacter baumannii.

Key words: Schisandra chinensis fruit, Acinetobacter baumannii, Cefoperazone-sulbactam