Research on the expressions of KAI1 gene, TIMP-1 and MMP-9 and their correlations with clinicopathologic features of non-small cell lung cancer

doi:10.3969/j.issn.1673-8640.2014.03.019

Abstract

Abstract:

Objective　To investigate the expressions of KAI1 gene,tissue inhibitor 1 of metalloproteinase (TIMP-1) and matrix metalloproteinase 9 (MMP-9) in non-small cell lung cancer (NSCLC) and their correlations with clinicopathologic features of NSCLC. Methods　The expressions of KAI1,TIMP-1 and MMP-9 in 73 specimens of NSCLC tissues,51 specimens of corresponding adjacent tissues and 13 specimens of non-cancerous lung tissue were determined by immunohistochemistry. Their correlations with clinicopathologic features were analyzed by χ² test and Pearson analysis. Results　In 73 specimens of NSCLC tissues and 64 cases of corresponding adjacent and non-cancerous lung tissues,the positive rates of KAI1 and TIMP-1 were 39.7%,74.0% and 90.6%,37.5% with statistical significance (P<0.05),and the positive rates of MMP-9 were 79.4%,67.1% without statistical significance (P>0.05). The expression of KAI1 was correlated to TNM stage,lymph node metastasis,histologic subtype and differentiation with statistical significance (P<0.05),and the TIMP-1 and MMP-9 were correlated to TNM stage and lymph node metastasis (P<0.05),but they were not correlated to age and sex. The expression of KAI1 was negatively correlated with the expressions of TIMP-1 and MMP-9 (r=-0.463 7,-0.344 5,P<0.05). Conclusions　The KAI1,TIMP-1 and MMP-9 are related to the development of lung cancer. The combination determination of them will be the important prognosis reference indicator for the occurrence and development of NSCLS.

Key words: 1 gene, Tissue inhibitor 1 of metalloproteinase, Matrix metalloproteinase 9, Lung neoplasm, Non-small cell

CLC Number:

R446.62

ZHU Bo, ZHAO Huiliu, WANG Ying, LAO Ming, HUANG Zhaodong, LIU Zhimin, XIE Juan, OU Chao.. Research on the expressions of KAI1 gene, TIMP-1 and MMP-9 and their correlations with clinicopathologic features of non-small cell lung cancer[J]. , 2014, 29(3): 279-282.

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