Abstract:

Objective To investigate the pathogen infection and antibiotic resistance in patients with malignant tumor undergoing radiotherapy and chemotherapy in Shanghai Cancer Center, Fudan University during recent 2 years. Methods A total of 305 strains of pathogens were identified from clinical specimens in malignant tumor patients undergoing radiotherapy and chemotherapy by VITEK-32 automatic microbiology analysis system and common methods from January 2010 to December 2011. The drug sensitivity test was detected according to the guideline of the Clinical and Laboratory Standards Institute (CLSI). Results The most common specimen sources were respiratory tract,followed by urine and blood. The main pathogens were gram negative organisms (57.7% and 46.5%),in which still Acinetobacter baumannii,Escherichia coli and Pseudomonas aeruginosa were the first 3 main kinds of pathogens during the 2 years. The prevalences of extended spectrum beta-lactamases (ESBLs) in the strains of Escherichia coli were 57.1% in 2010 and 28.6% in 2011. The following infection was fungus infection (27.0% in 2011 and 20.8% in 2010),among which Candida was the main pathogen. The gram positive organisms in 2011 were higher than those in 2010,and the percentage of methicillin-resistant Staphylococcus aureus decreased from 32.0% to 21.3% of the gram positive organisms. No strains were found resistant to vancomycin. Conclusions The main pathogens are contributed mostly by gram negative organisms in patients with malignant tumor undergoing radiotherapy and chemotherapy. Attentions should be paid to the pathogen infection determination and antibiotic resistance monitoring. It will provide the reference for the clinical dignosis.

Key words: Pathogen, Antibiotic resistance, Cancer patient