组蛋白乳酸化与疾病关系研究进展

doi:10.3969/j.issn.1673-8640.2024.07.015

摘要/Abstract

摘要：

组蛋白是染色质的主要蛋白组分，对生物遗传信息的调控有重要作用。乳酸作为细胞代谢的常见产物，可影响细胞遗传信息的表达。组蛋白在相关酶的作用下，会发生多种基团的化学修饰，其中乳酸化是重要的化学修饰之一。文章主要综述了组蛋白乳酸化的发生及其影响因素、组蛋白乳酸化与常见疾病的相互关系及治疗相关的研究进展。

关键词: 组蛋白, 乳酸化修饰, 疾病

Abstract:

Histones are the main protein components of chromatin and play roles in the regulation of biological genetic information. As a common product of cell metabolism，lactic acid can affect the expression of cell genetic information. Under the action of related enzymes，histones can undergo chemical modifications of various groups，among which lactation is one of the important chemical modifications. This review mainly focuses on the occurrence and influencing factors of histone lactation，the relationship between histone lactation and common diseases and the research progress of treatment.

Key words: Histone, Lactic acid modification, Disease

中图分类号:

R446.1

匡贤栋, 蔡馨, 汤冬玲, 张平安. 组蛋白乳酸化与疾病关系研究进展[J]. 检验医学, 2024, 39(7): 704-708.

KUANG Xiandong, CAI Xin, TANG Dongling, ZHANG Ping'an. Research progress on relationship between histone lactation and disease[J]. Laboratory Medicine, 2024, 39(7): 704-708.

图/表 2

参考文献 30

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相关疾病	细胞	组蛋白乳酸化位点	参考文献
肺纤维化	巨噬细胞	精氨酸酶1	[4]
脓毒症	巨噬细胞	血小板衍生生长因子A	[5]
脓毒症	巨噬细胞	血小板反应蛋白	[5]
脓毒症	巨噬细胞	血管内皮生长因子A的近端启动子区	[5]
无	巨噬细胞	组蛋白H3K18	[6]
无	巨噬细胞	高迁移率族蛋白B1	[6]
肺动脉高压	巨噬细胞	组蛋白H4K5	[10]
恶性胸腔积液	自然杀伤细胞	叉状头转录因子P3 启动子前端	[7]
肝细胞癌	肝细胞	组蛋白ABCF1-K430	[3]
肝细胞癌	肺细胞	组蛋白ABCF1-K430	[3]
肺动脉高压	肺动脉平滑肌细胞	缺氧诱导因子1α	[10]
阿尔茨海默病	脑细胞	组蛋白H4K12	[8]
脑缺血	脑细胞	高迁移率族蛋白B1	[11]
前列腺癌	前列腺癌细胞	组蛋白H3K18	[9]
肺腺癌	肌细胞	组蛋白H3K18	[9]
无	原始胚胎神经元	组蛋白H1	[12]
无	胚胎成纤维细胞	组蛋白H3K18	[12]
眼黑色素瘤	黑色素瘤细胞	组蛋白H3K18	[12]
无	肺支气管上皮细胞	组蛋白H4K8	[12]

相关疾病	细胞	组蛋白乳酸化位点	参考文献
肺纤维化	巨噬细胞	精氨酸酶1	[4]
脓毒症	巨噬细胞	血小板衍生生长因子A	[5]
脓毒症	巨噬细胞	血小板反应蛋白	[5]
脓毒症	巨噬细胞	血管内皮生长因子A的近端启动子区	[5]
无	巨噬细胞	组蛋白H3K18	[6]
无	巨噬细胞	高迁移率族蛋白B1	[6]
肺动脉高压	巨噬细胞	组蛋白H4K5	[10]
恶性胸腔积液	自然杀伤细胞	叉状头转录因子P3 启动子前端	[7]
肝细胞癌	肝细胞	组蛋白ABCF1-K430	[3]
肝细胞癌	肺细胞	组蛋白ABCF1-K430	[3]
肺动脉高压	肺动脉平滑肌细胞	缺氧诱导因子1α	[10]
阿尔茨海默病	脑细胞	组蛋白H4K12	[8]
脑缺血	脑细胞	高迁移率族蛋白B1	[11]
前列腺癌	前列腺癌细胞	组蛋白H3K18	[9]
肺腺癌	肌细胞	组蛋白H3K18	[9]
无	原始胚胎神经元	组蛋白H1	[12]
无	胚胎成纤维细胞	组蛋白H3K18	[12]
眼黑色素瘤	黑色素瘤细胞	组蛋白H3K18	[12]
无	肺支气管上皮细胞	组蛋白H4K8	[12]