血浆D-二聚体水平在乳腺癌患者中的临床价值

doi:10.3969/j.issn.1673-8640.2018.12.014

检验医学 ›› 2018, Vol. 33 ›› Issue (12): 1120-1122.DOI: 10.3969/j.issn.1673-8640.2018.12.014

血浆D-二聚体水平在乳腺癌患者中的临床价值

金梓涵¹, 冯同保², 戚春建³, 苏兆亮¹

1.江苏大学医学院,江苏镇江 212013
2.常州市第二人民医院检验科,江苏常州 213000
3.常州市第二人民医院中心实验室,江苏常州 213000

收稿日期:2017-10-10 出版日期:2018-12-26 发布日期:2018-12-27
作者简介:null
作者简介：金梓涵,女,1988年生,学士,技师,主要从事分子免疫学检验和临床检验诊断工作。
基金资助:
国家自然科学基金（31601156）

Role of plasma D-dimer level in breast cancer patients

JIN Zihan¹, FENG Tongbao², QI Chunjian³, SU Zhaoliang¹

1. School of Medicine,Jiangsu University,Zhenjiang 212013,Jiangsu,China
2. Department of Clinical Laboratory,Changzhou Second People's Hospital,Changzhou 213000,Jiangsu,China
3. Central Laboratory,Changzhou Second People's Hospital,Changzhou 213000,Jiangsu,China

Received:2017-10-10 Online:2018-12-26 Published:2018-12-27

摘要/Abstract

摘要：

目的探讨血浆D-二聚体（DD）水平在乳腺癌患者中的临床价值。方法采用免疫比浊法检测98例乳腺癌患者（乳腺癌组）以及100名女性体检健康者（健康对照组）血浆DD水平。对血浆DD水平与乳腺癌临床分期、转移和预后的关系进行统计分析。结果乳腺癌组血浆DD水平显著高于健康对照组（P<0.01）,血浆DD水平与临床分期、转移有关（P<0.05）。人类表皮生长因子受体-2（HER-2）阳性患者血浆DD水平高于HER-2阴性患者（P<0.05）。结论乳腺癌患者血浆DD水平与临床分期、转移有关,对辅助诊断乳腺癌有一定价值。

关键词: D-二聚体, 乳腺癌, 临床分期, 转移

Abstract:

Objective To investigate the role of plasma D-dimer（DD） level in patients with breast cancer.Methods Plasma DD levels of 98 patients with breast cancer（breast cancer group） and 100 healthy subjects（healthy control group） were determined by immune nephelometry. The relations between plasma DD level and clinical stages,metastasis and prognosis of breast cancer patients were analyzed statistically.Results The levels of plasma DD were higher in breast cancer group than those in healthy control group（P<0.01）. The levels of plasma DD had relations with different clinical stages and metastasis（P<0.05）. The levels of plasma DD in human epidermal growth factor receptor-2（HER-2） positive patients were higher than those in HER-2 negative patients（P<0.05）.Conclusions Plasma DD levels are related with clinical stages and metastasis in breast cancer patients,which can be used for the auxiliary diagnosis of breast cancer.

Key words: D-dimer, Breast cancer, Clinical stage, Metastasis

中图分类号:

R446.1

金梓涵, 冯同保, 戚春建, 苏兆亮. 血浆D-二聚体水平在乳腺癌患者中的临床价值[J]. 检验医学, 2018, 33(12): 1120-1122.

JIN Zihan, FENG Tongbao, QI Chunjian, SU Zhaoliang. Role of plasma D-dimer level in breast cancer patients[J]. Laboratory Medicine, 2018, 33(12): 1120-1122.

图/表 6

图1 乳腺癌组与健康对照组血浆DD水平比较

图2 乳腺癌转移组与未转移组血浆DD水平比较

图3 乳腺癌各分期血浆DD水平比较

图4 HER-2阳性和阴性患者血浆DD水平比较

图5 p53阳性和阴性患者血浆DD水平比较

图6 不同乳腺癌预后血浆DD水平比较

参考文献 9

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血浆D-二聚体水平在乳腺癌患者中的临床价值

Role of plasma D-dimer level in breast cancer patients

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