高同型半胱氨酸血症的神经毒性机制研究进展

摘要/Abstract

摘要：

高同型半胱氨酸血症(HHcy)是由同型半胱氨酸(Hcy)代谢异常引起的。HHcy既是心脑血管疾病的独立危险因素,也与多种神经退行性疾病和精神疾病密切相关。HHcy主要通过血管和神经毒性发挥致病作用。本文就近年来HHcy的致神经毒性作用的机制做一综述。

关键词: 同型半胱氨酸, 高同型半胱氨酸血症, 神经毒性

Abstract:

Hyperhomocysteinemia (HHcy) is caused by abnormal metabolism of homocysteine (Hcy). HHcy is not only an independent risk factor for cardiovascular and cerebrovascular diseases,but also closely correlated with a variety of neurodegenerative and mental diseases.HHcy mainly plays a pathogenic role by vascular and neuron neurotoxicity. In this article, we review the mechanisms of HHcy neurotoxicity in recent years.

Key words: Homocysteine, Hyperhomocysteinemia, Neurotoxicity

中图分类号:

R446.1

王晓燕, 王伟灵. 高同型半胱氨酸血症的神经毒性机制研究进展[J]. 检验医学, 2014, 29(12): 1263-1267.

WANG Xiaoyan, WANG Weiling. Research advance on mechanisms of hyperhomocysteinemia neurotoxicity[J]. , 2014, 29(12): 1263-1267.

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