关键词: 同型半胱氨酸, B型钠尿肽, 纤维蛋白原, 下肢深静脉血栓, 剖宫产

Abstract:

Objective To investigate the predictive roles of serum homocysteine（Hcy），B-type natriuretic peptide（BNP）and fibrinogen（Fib）in patients with deep venous thrombosis（DVT）of lower extremity after cesarean section. Methods A total of 74 females who underwent cesarean section in the Fifth Hospital of Zhangjiakou City from March 2017 to April 2019 were enrolled，which included 37 female patients with postoperative DVT（DVT group）and 37 females without lower extremity DVT（healthy control group）. Totally，30 birth-giving female patients with lower extremity DVT during the same period were enrolled as disease control group. Wells score was used to evaluate the clinical characteristics of patients in DVT group. The differences of Hcy，BNP and Fib among the groups were evaluated. Receiver operating characteristic（ROC）curve and area under curve（AUC）were used to evaluate the efficiency of each indicator in predicting lower extremity DVT after cesarean section. Pearson correlation analysis was used to evaluate the correlation among all the indicators. Results The levels of Hcy，BNP and Fib in DVT group and disease control group were higher than those in healthy control group（P<0.05），and there was no statistical significance in Hcy，BNP and Fib between DVT group and disease control group（P>0.05）. There was statistical significance in the levels of Hcy，BNP and Fib among lower extremity DVT patients with mild，moderate and severe degrees（P<0.05），and the levels of Hcy，BNP and Fib were increased with the increase of Wells scores. ROC curve analysis showed that the AUC of Hcy，BNP and Fib single and combined determinations to predict lower extremity DVT after cesarean section were 0.912，0.861，0.877 and 0.946，respectively. Conclusions Serum Hcy，BNP and Fib have good clinical predictive values for lower extremity DVT after cesarean section.

Key words: Homocysteine, B-type natriuretic peptide, Fibrinogen, Deep venous thrombosis, Cesarean section