检验医学 ›› 2014, Vol. 29 ›› Issue (8): 806-808.DOI: 10.3969/j.issn.1673-8640.2014.08.005

• 临床应用研究·论著 • 上一篇    下一篇

962例尿培养病原菌分布及耐药性分析

吴芳芳1, 许纹1, 杨乐园2   

  1. 1. 上海建工医院检验科, 上海 200083;
    2. 上海市第一人民医院宝山分院, 上海 200940
  • 收稿日期:2013-12-22 出版日期:2014-08-30 发布日期:2014-09-05
  • 作者简介:吴芳芳,女,1968年生,主管技师,学士,主要从事微生物检验工作。

Distribution and drug resistance analysis on 962 cases of urinary culture pathogenic bacteria

WU Fangfang1, XU Wen1, YANG Leyuan   

  1. 1. Department of Clinical Laboratory, Shanghai Jiangong Hospital, Shanghai 200083, China;
    2. Baoshan Branch, Shanghai First People's Hospital, Shanghai 200940, China
  • Received:2013-12-22 Online:2014-08-30 Published:2014-09-05

摘要: 目的 分析尿路感染患者的细菌分布及耐药状况,为临床合理选用抗菌药物提供依据。方法 采用回顾性调查方法对尿标本中分离的菌株进行分析。结果 共分离菌株962株,其中革兰阴性杆菌701株(72.9%)、革兰阳性球菌261株(27.1%);大肠埃希菌429株(44.6%)、肠球菌属228株(23.7%)、肺炎克雷伯菌83株(8.6%)。大肠埃希菌和肺炎克雷伯菌对喹诺酮的耐药率分别为77.9%和47.0%;对头孢噻肟耐药率分别为62.9%和57.8%。屎肠球菌对各种抗菌药物的耐药率明显高于粪肠球菌,未检出对万古霉素耐药的菌株。结论 尿培养阳性的主要致病菌以大肠埃希菌为代表的革兰阴性杆菌为主,对喹诺酮类和第3、4代头孢菌素的耐药情况严重。

关键词: 尿培养, 细菌分布, 耐药性

Abstract: Objective To analyze bacterial distribution and drug resistance of urinary tract infection, and to provide the reference for clinical rational use of antimicrobial agents. Methods A retrospective investigation was performed. The isolates from urine specimens were analyzed. Results There were 962 isolates including 701 isolates of gram negative bacilli (72.9%) and 261 isolates of gram positive cocci (27.1%). There were Escherichia coli (429 isolates, 44.6%), following 228 isolates of Enterococcus (23.7%) and 83 isolates of Klebsiella pneumoniae (8.6%). The drug resistance rates of Escherichia coli and Klebsiella pneumoniae to quinolone were 77.9% and 47.0%. The drug resistance rates to cefotaxime were 62.9%and 57.8%. The drug resistance rate of Enterococcus faecium was higher than that of Enterococcus faecalis, and there was no isolate resistant to vancomycin. Conclusions The main pathogenic bacteria of urinary culture are Escherichia coli as the representative of gram negative bacilli. The drug resistances to quinolone and the 3rd and 4th generation cephalosporins are serious.

Key words: Urinary culture, Bacterial distribution, Drug resistance

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