关键词: 氨基末端B型钠尿肽原, 心肌肌钙蛋白I, 心力衰竭

Abstract: Objective　To investigate the application of combined detection of the N-terminal pro-B-type natriuretic peptide（NT-proBNP）and cardiac troponin I（cTnI）in the diagnosis and treatment of acute heart failure（HF）patients in emergency department.   Methods　Enzyme-linked immunosorbent fluorescence assay was used to determine plasma NT-proBNP and cTnI levels in 708 patients with cardiovascular diseases（195 patients with HF and 513 patients with non-HF). Acoording to the New York Heart Assoeiation（NYHA）cardiac function grades，the HF patients were chassified into Grade Ⅰ-Ⅳ. The results were expressed by medians（quartiles). The results were analyzed statistically. Results　The levels of NT-proBNP and cTnI in HF group were 3 718（1 035-12 258）ng/L and 7.18（2.05-14.16）μg/L，respectively，which were significantly higher than those in [145（30-585）ng/L for NT-proBNP and 0.66（0.06-1.99）μg/L for cTnI，P＜0.01]. Statistical significance was also observed when comparing NT-proBNP and cTnI levels of the patients with HF at NYHA Grade Ⅱ，Ⅲ and Ⅳ （P＜0.05). Furthermore，the sensitivity（99%）and specificity（90%）for the diagnosis of HF with the combined detection of NT-proBNP and cTnI were much higher than those with either the detection of NT-proBNP or cTnI alone（P＜0.05). Conclusions　The combined detection of NT-proBNP and cTnI has valuable significance in the diagnosis and treatment of HF in emergency department.

Key words: N-terminal pro-brain natriuretic peptides, Cardiac troponin I, Cardiac Failure