关键词: 超氧化物歧化酶, 总抗氧化状态, 丙二醛, 谷胱甘肽过氧化物酶, 谷胱甘肽还原酶, 前列腺增生, 前列腺癌

Abstract:

Objective To investigate the relationship between oxidative stress markers of peripheral blood oxidative stress markers [glutathione peroxidase（GPX），superoxide dismutase（SOD），total antioxidant status（TAS），malondialdehyde（MDA） and glutathione reductase（GR）] with prostatic hyperplasia and prostate cancer. Methods A total of 222 patients with prostatic hyperplasia，136 patients with prostate cancer and 194 healthy subjects were enrolled. The levels of GPX，SOD，GR，TAS and MDA were determined. According to Gleason score，prostate cancer patients were classified into 6-7，8 and 9-10 groups. Binary Logistic regression analysis was used to evaluate the relationship between oxidative stress markers with prostatic hyperplasia and prostate cancer. Results The levels of SOD and TAS in healthy control group，prostatic hyperplasia group and prostate cancer group，were decreased successively（P<0.001），and MDA levels were increased（P<0.001）. There was no statistical significance in GPX and GR levels among the 3 groups（P>0.05）. For Gleason score 6-7，8 and 9-10 groups，SOD and TAS levels were decreased（P<0.001）. There was no statistical significance in the levels of GPX，GR and MDA among the 3 groups（P>0.05）. Binary Logistic regression analysis showed that with the healthy control group as a reference，and after adjusting for age，body mass index，smoking history，alcohol history，hypertension history and diabetes mellitus history，SOD decreasing，TAS decreasing and MDA increasing were independent risk factors for prostatic hyperplasia [odds ratios（OR）were 1.014，8.117 and 1.020] and prostate cancer （OR were 1.054，22.894 and 1.256，respectively）. With the prostatic hyperplasia group as a reference，after adjusting for age，body mass index，smoking history，alcohol history，hypertension history and diabetes mellitus history，SOD decreasing，TAS decreasing and MDA increasing were independent risk factors for prostate cancer（OR were 1.040，15.577 and 1.012，respectively）. Conclusions The decrease of SOD and TAS levels and the increase of MDA levels may be related to the occurrence of prostatic hyperplasia and prostate cancer，suggesting that oxidative stress disorder plays a role in the occurrence and development of prostatic hyperplasia and prostate cancer.

Key words: Superoxide dismutase, Total antioxidant status, Malondialdehyde, Glutathione peroxidase, Glutathione reductase, Prostatic hyperplasia, Prostate cancer