中重度牙周炎合并银屑病与代谢综合征各组分的关系

doi:10.3969/j.issn.1673-8640.2022.02.006

摘要/Abstract

摘要：

目的探讨中重度牙周炎合并银屑病与代谢综合征（MS）各组分的相关性。方法选取中重度牙周炎患者50例（中重度牙周炎组）、银屑病患者50例（银屑病组）、中重度牙周炎合并银屑病患者50例（中重度牙周炎合并银屑病组）,以健康体检者50名作为正常对照组。检测所有对象的血压、糖化血红蛋白（HbA_1c）、血糖（Glu）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）。采用多因素Logistic回归分析评估疾病发生的危险因素。结果中重度牙周炎组、银屑病组TC和LDL-C水平高于正常对照组（P<0.05）。中重度牙周炎合并银屑病组TG、LDL-C、TC和HbA_1c水平高于中重度牙周炎组（P<0.05）,TG、LDL-C、TC水平高于银屑病组（P<0.05）。中重度牙周炎合并银屑病组TG、LDL-C、TC、Glu和HbA_1c显著高于正常对照组（P<0.01）。多因素Logistic回归分析结果显示,LDL-C升高是中重度牙周炎发生的危险因素[比值比（OR）=1.873,95%可信区间（CI）为1.113~3.154],TC升高是银屑病发生的危险因素（OR=1.527,95%CI为1.012~2.304）;TC、HbA_1c升高是中重度牙周炎合并银屑病发生的危险因素（OR值分别为2.728、3.108,95%CI分别为1.572~4.732、1.283~7.533）。结论中重度牙周炎合并银屑病患者糖、脂代谢紊乱情况更为严重,TC、HbA_1c升高是中重度牙周炎合并银屑病发生的危险因素。

关键词: 代谢综合征, 牙周炎, 银屑病

Abstract:

Objective To investigate the correlation between metabolic syndrome（MS） and moderate-to-severe periodontitis complicated with psoriasis. Methods A total of 50 patients with moderate-to-severe periodontitis,50 patients with psoriasis and 50 patients with moderate-to-severe periodontitis complicated with psoriasis were enrolled. Totally,50 healthy subjects were enrolled as control group. Blood pressure,glycated hemoglobin A_1c（HbA_1c）,glucose（Glu）,triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C） were determined. Multivariate Logistic regression analysis was used to assess the risk factors for disease development in each group. Results TC and LDL-C in moderate-to-severe periodontitis group and psoriasis group were higher than those in control group（P<0.05）. TG,LDL-C,TC and HbA_1c were higher in moderate-to-severe periodontitis complicated with psoriasis group than those in moderate-to-severe periodontitis group（P<0.05）,and TG,LDL-C and TC were higher than those in psoriasis group（P<0.05）. In moderate-to-severe periodontitis complicated with psoriasis group,TG,LDL-C,TC,Glu and HbA_1c were higher than those in control group（P<0.01）. Multivariate Logistic regression analysis showed that elevated LDL-C was a risk factor for the development of moderate-to-severe periodontitis [odds ratio（OR）=1.873,95% confidence interval（CI） 1.113-3.154],elevated TC was a risk factor for the development of psoriasis（OR=1.527,95%CI 1.012-2.304）,and elevated TC and HbA_1c were risk factors for the development of moderate-to-severe periodontitis complicated with psoriasis（OR=2.728 and 3.108,95%CI 1.572-4.732 and 1.283-7.533,respectively）. Conclusions Patients with moderate-to-severe periodontitis complicated with psoriasis show more significant disorders of MS-related components than patients with periodontitis or psoriasis alone,and elevated TC and HbA_1c are risk factors for the development of moderate-to-severe periodontitis complicated with psoriasis.

Key words: Metabolic syndrome, Periodontitis, Psoriasis

中图分类号:

R446.1

陈梁, 李琳, 李霞, 张岩, 吴炯睿, 高益鸣. 中重度牙周炎合并银屑病与代谢综合征各组分的关系[J]. 检验医学, 2022, 37(2): 126-129.

CHEN Liang, LI Lin, LI Xia, ZHANG Yan, WU Jiongrui, GAO Yiming. Correlation between metabolic syndrome and moderate-to-severe periodontitis complicated with psoriasis[J]. Laboratory Medicine, 2022, 37(2): 126-129.

图/表 4

参考文献 17

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组别	例数	TC/ （mmol/L）	TG/ （mmol/L）	LDL-C/ （mmol/L）	HDL-C/（mmol/L）	Glu/ （mmol/L）	HbA_1c/%	收缩压/kPa
正常对照组	50	4.67±1.03	1.53±0.41	2.86±0.90	1.23±0.22	5.43±0.70	5.50±0.52	16.61±2.31
牙周炎组	50	5.10±0.85^*	1.60±0.43	3.26±0.70^*	1.22±0.23	5.68±0.57	5.61±0.53	16.53±2.21
银屑病组	50	5.09±0.99^*	1.57±0.50	3.24±0.75^*	1.23±0.22	5.61±0.57	5.67±0.43	16.62±1.93
牙周炎合并银屑病组	50	5.48±0.94^**#△	1.83±0.53^**#△	3.55±0.71^**#△	1.21±0.24	5.88±0.81^**	5.86±0.57 ^**#	17.40±2.56

组别	例数	TC/ （mmol/L）	TG/ （mmol/L）	LDL-C/ （mmol/L）	HDL-C/（mmol/L）	Glu/ （mmol/L）	HbA_1c/%	收缩压/kPa
正常对照组	50	4.67±1.03	1.53±0.41	2.86±0.90	1.23±0.22	5.43±0.70	5.50±0.52	16.61±2.31
牙周炎组	50	5.10±0.85^*	1.60±0.43	3.26±0.70^*	1.22±0.23	5.68±0.57	5.61±0.53	16.53±2.21
银屑病组	50	5.09±0.99^*	1.57±0.50	3.24±0.75^*	1.23±0.22	5.61±0.57	5.67±0.43	16.62±1.93
牙周炎合并银屑病组	50	5.48±0.94^**#△	1.83±0.53^**#△	3.55±0.71^**#△	1.21±0.24	5.88±0.81^**	5.86±0.57 ^**#	17.40±2.56

项目	β值	标准误	Wald值	OR值（95%CI）	P值
TC	0.106	2.112	0.000	1.006（0.016~63.195）	0.745
TG	0.013	0.809	0.000	1.006（0.206~4.915）	0.910
LDL-C	0.526	0.266	5.581	1.873（1.113~3.154）	0.018
HDL-C	0.278	2.241	0.036	0.652（0.008~52.732）	0.598
Glu	2.151	0.516	2.132	2.123（0.773~5.833）	0.143
HbA_1c	0.399	0.624	0.299	0.711（0.209~2.414）	0.527
收缩压	0.158	0.013	0.587	0.990（0l965~1.016）	0.691

项目	β值	标准误	Wald值	OR值（95%CI）	P值
TC	0.106	2.112	0.000	1.006（0.016~63.195）	0.745
TG	0.013	0.809	0.000	1.006（0.206~4.915）	0.910
LDL-C	0.526	0.266	5.581	1.873（1.113~3.154）	0.018
HDL-C	0.278	2.241	0.036	0.652（0.008~52.732）	0.598
Glu	2.151	0.516	2.132	2.123（0.773~5.833）	0.143
HbA_1c	0.399	0.624	0.299	0.711（0.209~2.414）	0.527
收缩压	0.158	0.013	0.587	0.990（0l965~1.016）	0.691

项目	β值	标准误	Wald值	OR值（95%CI）	P值
TC	0.423	0.210	4.361	1.527（1.012~2.304）	0.044
TG	0.056	0.658	0.474	0.636（0.175~2.307）	0.813
LDL-C	0.140	1.884	0.030	0.721（0.018~28.933）	0.282
HDL-C	0.495	2.087	0.702	0.174（0.003~10.401）	0.482
Glu	1.740	0.473	0.129	1.186（0.469~2.998）	0.187
HbA_1c	2.184	0.624	0.622	1.636（0.481~5.560）	0.139
收缩压	0.058	0.013	0.110	0.996（0.970~1.022）	0.810