关键词: 异基因造血干细胞移植, 噬血细胞性淋巴组织细胞增多症, 骨髓

Abstract:

Objective To analyze the characteristics of hemophagocytic phenomenon after allogeneic hematopoietic stem cell transplantation（allo-HSCT）. Methods Two patients with hemophagocytic lymphohistiocytosis（HLH） after allo-HSCT were enrolled from Shanghai General Hospital,and the possible causes were discussed. Results The admission diagnosis of case 1 was immunodeficiency disease,granulocyte implantation was found after allo-HSCT for 13 d,hemoglobin and platelet were low,and coagulation function was poor. Gastrointestinal bleeding,cytomegalovirus enteritis and lung infection appeared,and hemophagocytic cells were visible in bone marrow smear. The admission diagnosis of case 2 was acute monocytic leukemia,granulocyte implantation was found after allo-HSCT for 14 d,and peripheral blood cells continued to decrease after allo-HSCT for 42 d. Fever,high ferritin and hemophagocytic phenomenon were visible,and stem cell transplantation chimeric rate declined progressively. Conclusions The hemophagocytic phenomenon after allo-HSCT is very rare,the progress is rapid,the prognosis is poor,and the hemophagocytic phenomenon is often caused by infection. When hemophagocytic phenomenon occurs after hematopoietic stem cell transplantation,it should actively check infection,determine whether primary disease recurs,detect patient and parent related genes,and seek a early therapy and better prognosis as soon as possible.

Key words: Allogeneic hematopoietic stem cell transplantation, Hemophagocytic lymphohistiocytosis, Bone marrow