淋巴细胞参数在弥漫性大B细胞淋巴瘤诊断中的价值

doi:10.3969/j.issn.1673-8640.2019.12.012

摘要/Abstract

摘要：

目的探讨淋巴细胞参数在弥漫性大B细胞淋巴瘤（DLBCL）诊断中的价值。方法选取体检健康者60名,作为对照组。另选取44例初诊DLBCL患者、24例慢性淋巴细胞白血病（CLL）患者、42例其他非霍奇金淋巴瘤（NHL）患者和40例传染性单核细胞增多症（IM）患者,比较DLBCL与其他各组淋巴细胞参数的差异。采用受试者工作特征（ROC）曲线探讨淋巴细胞参数对DLBCL的诊断效能。结果 DLBCL组与对照组LY-X、LY-Y、LY-WZ差异有统计学意义,其诊断DLBCL的曲线下面积（AUC）分别为0.644、0.655、0.742,最佳临界值分别为76.9、69.1、536;DLBCL组与CLL组LY-X、LY-WX、LY-WY、LY-WZ差异有统计学意义,其诊断DLBCL的AUC分别为0.772、0.608、0.863、0.827,最佳临界值分别为79.4、612、1 020、533;DLBCL组与其他NHL组LY-WZ差异有统计学意义,其诊断DLBCL的AUC为0.575,最佳临界值为588;DLBCL组与IM组LY-Z、LY-WX、LY-WY、LY-WZ差异有统计学意义,其诊断DLBCL的AUC分别为0.772、0.561、0.777、0.887,最佳临界值分别为60.9、612、1 022、633。结论淋巴细胞参数对DLBCL有一定的诊断价值。

关键词: 弥漫性大B细胞淋巴瘤, 淋巴细胞参数, 诊断价值

Abstract:

Objective To investigate the roles of lymphocyte parameters in the diagnosis of diffuse large B-cell lymphoma（DLBCL）. Methods A total of 60 healthy subjects（healthy control group）,44 patients with DLBCL,24 patients with chronic lymphocytic leukaemia（CLL）,42 patients with other non-Hodgkin lymphomas（NHL） and 40 patients with infectious mononucleosis（IM） were enrolled,and their lymphocyte parameters were determined. The difference between DLBCL and the other groups was evaluated. Receiver operating characteristic（ROC） curve was used to evaluate the diagnostic efficiency of different lymphocyte parameters for DLBCL. Results Compared with healthy control group,DLBCL group had statistical significance in LY-X,LY-Y and LY-WZ,their areas under ROC curves（AUC） were 0.644,0.655 and 0.742,and the optimal cut-off values were 76.9,69.1 and 536,respectively. Compared with CLL group,the differences of LY-X,LY-WX,LY-WY and LY-WZ were statistically significant,the AUC were 0.772,0.608,0.863 and 0.827,and the optimal cut-off values were 79.4,612,1 020 and 533,respectively. Compared with other NHL group,LY-WZ had statistical significance,the AUC was 0.575,and the optimal cut-off value was 588. Compared with IM group,LY-Z,LY-WX,LY-WY and LY-WZ were statistically significant,the AUC were 0.772,0.561,0.777 and 0.887,and the optimal cut-off values were 60.9,612,1 022 and 633,respectively. Conclusions Lymphocyte parameters have a certain value for the diagnosis of DLBCL.

Key words: Diffuse large B-cell lymphoma, Lymphocyte parameter, Diagnostic value

中图分类号:

R446.1

袁钦伟, 郭永灿, 陈忱, 叶润发. 淋巴细胞参数在弥漫性大B细胞淋巴瘤诊断中的价值[J]. 检验医学, 2019, 34(12): 1114-1117.

YUAN Qinwei, GUO Yongcan, CHEN Chen, YE Runfa. Roles of lymphocyte parameters in the diagnosis of diffuse large B-cell lymphoma[J]. Laboratory Medicine, 2019, 34(12): 1114-1117.

图/表 5

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组别	LY-X	LY-Y	LY-Z	LY-WX	LY-WY	LY-WZ
对照组	76.5±3.0	67.4±4.2	59.3±2.5	498±48	850±62	590±38
DLBCL组	78.5±3.8	70.3±5.2	59.6±1.6	524±61	889±99	529±73
CLL组	82.0±11.4	71.8±10.9	59.4±2.7	547±80	993±235	679±191
其他NHL组	82.0±10.9	72.8±8.4	59.1±2.8	732±71	912±141	661±201
IM组	79.1±3.1	72.5±5.1	60.3±2.3	675±186	1 241±311	717±128

组别	LY-X	LY-Y	LY-Z	LY-WX	LY-WY	LY-WZ
对照组	76.5±3.0	67.4±4.2	59.3±2.5	498±48	850±62	590±38
DLBCL组	78.5±3.8	70.3±5.2	59.6±1.6	524±61	889±99	529±73
CLL组	82.0±11.4	71.8±10.9	59.4±2.7	547±80	993±235	679±191
其他NHL组	82.0±10.9	72.8±8.4	59.1±2.8	732±71	912±141	661±201
IM组	79.1±3.1	72.5±5.1	60.3±2.3	675±186	1 241±311	717±128