关键词: ApoE基因, 基因多态性, 高脂血症, 指导用药

Abstract:

Objective To study the relationship between apolipoprotein E （ApoE）gene polymorphism and blood lipid metabolism disorder,and to guide rational drug use. Methods A total of 142 hyperlipidemia patients were enrolled from January 2016 to December 2016. Patients with one of total cholesterol （TC）,triglyceride （TG） and low-density lipoprotein cholesterol （LDL-C）increasing were enrolled. The genotypes of ApoE gene were detected by gene chip technology. The relationship between different genotypes with blood lipid metabolism was evaluated. Results Among the 142 hyperlipidemia patients,there were 51 cases of high TC,70 cases of high TG and 49 cases of high LDL-C. ApoEgene showed polymorphic distribution. The distribution frequency of E3 allele was the highest,accounting for 65.42%,followed by E4 （17.53%） and E2 （17.05%）. The levels of TC and LDL-C in E4 group were higher, and the TG level in E2 group was higher. There was no statistical significance for TG and LDL-C levels among the 3 genotypes （P>0.05）. E4 genotype had statistical significance for TC levels compared with E2 and E3 genotypes （P<0.05）. Conclusions ApoEgene presents polymorphic distribution. Hyperlipidemia is an independent factor for atherosclerosis and cardiovascular diseases. Blood lipid levels are influenced from different genotypes. Targeting different ApoE gene genotypes, individualized treatment programs may be developed for patients, in order to select appropriate lipid-lowering drugs.

Key words: Apolipoprotein E gene, Gene polymorphism, Hyperlipidemia, Medication guide