自身免疫性疾病新型自身抗体研究进展

doi:10.3969/j.issn.1673-8640.2017.06.021

摘要/Abstract

摘要：

自身免疫性疾病（AID）是指机体免疫系统对自身成分的免疫耐受被打破,引起自身组织损伤的疾病。而自身抗体是诊断AID的重要依据,每种AID都具有其特征性的自身抗体谱。近年来,自身抗体的研究发展较快,文章就常见的AID部分新发现的自身抗体研究进展作一综述。

关键词: 新型自身抗体, 自身免疫性疾病, 研究进展

Abstract:

For autoimmune diseases （AID）,the tolerance of immune system to self component is broken. Autoantibodies are important for diagnosing AID. Each AID has its unique autoantibody spectrum. The research on autoantibodies has gained a profound development in recent years. This review will focus on the latest development on the new types of autoantibodies for AID.

Key words: New types of autoantibodies, Autoimmune diseases, Research progress

中图分类号:

R446.62

周鑫昀, 陈惠综述, 沈立松审校. 自身免疫性疾病新型自身抗体研究进展[J]. 检验医学, 2017, 32(6): 543-548.

ZHOU Xinyun, CHEN Hui, SHEN Lisong. Research progress on the new types of autoantibodies in autoimmune diseases[J]. Laboratory Medicine, 2017, 32(6): 543-548.

参考文献 34

[1]	MALAGUARNERA M,CRISTALDI E,ROMANO G,et al.Autoimmunity in the elderly:implications for cancer[J].J Cancer Res Ther,2012,8(4):520-527.
[2]	茹晋丽,赵越,张莉芸,等. 抗细胞膜DNA抗体检测方法的建立及对系统性红斑狼疮诊断价值的临床应用研究[J]. 中华风湿病学杂志,2012,16(1):27-32.
[3]	YOSHIO T,ONDA K,NARA H,et al.Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychiatric systemic lupus erythematosus[J].Arthritis Rheum,2006,54(2):675-678.
[4]	YANG Y,YUAN C,SHEN S Q,et al.Autoantibodies to NR2A peptide of the glutamate/NMDA receptor in patients with seizure disorders in neuropsychiatric systemic lupus erythematosus[J]. Mediators Inflamm,2017,2017:5047898.
[5]	ABEDIAN Z,SAGAFI M,KENARI S A,et al. Anti-perinuclear factor as diagnostic marker in rheumatoid arthritis[J]. J Clin Diagn Res,2015,9(9):OC13-OC16.
[6]	李敬扬,周伦祥,易晴松,等. 抗核周因子、抗角蛋白抗体与类风湿因子联合检测在类风湿关节炎中的意义[J]. 中国现代医学杂志,2006,16(13):1996-1999.
[7]	STEINER G,SMOLEN J.Autoantibodies in rheumatoid arthritis and their clinical significance[J].Arthritis Res,2002,4(Suppl 2):S1-S5.
[8]	裴春红,赵春生.多指标联合检测在类风湿关节炎诊断中的临床价值分析[J].中国医学创新,2012,5(32):92.
[9]	AL-MUGHALES J A. Immunodiagnostic significance of anti-RA33 autoantibodies in Saudi patients with rheumatoid arthritis[J]. J Immunol Res,2015,2015:604305.
[10]	VOSSENAAR E R,DESPRES N,LAPOINTE E,et al.Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin[J].Arthritis Res Ther,2004,6(2):R142-R150.
[11]	RENGER F,BANG H,FEIST E,et al.Immediate determination of ACPA and rheumatoid factor-a novel point of care test for detection of anti-MCV antibodies and rheumatoid factor using a lateral- flow immunoassay[J].Arthritis Res Ther,2010,12(3):R120.
[12]	SIZOVA L.Diagnostic value of antibodies to modified citrullinated vimentin in early rheumatoid arthritis[J].Hum Immunol,2012,73(4):389-392.
[13]	ZAHRAN W E,MAHMOUD M I,SHALABY K A,et al.Unique correlation between mutated citrullinated vimentin IgG autoantibodies and markers of systemic inflammation in rheumatoid arthritis patients[J]. Indian J Clin Biochem,2013,28(3):272-276.
[14]	CHOI S W,LIM M K,SHIN D H,et al.Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis[J].J Korean Med Sci,2005,20(3):473-478.
[15]	DUBUCQUOI S,SOLAU-GERVAIS E,LEFRANC D,et al.Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases[J].Ann Rheum Dis,2004,63(4):415-419.
[16]	SHI J,KNEVEL R,SUWANNALAI P,et al.Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage[J]. Proc Natl Acad Sci U S A,2011,108(42):17372-17377.
[17]	YEE A,WEBB T,SEAMAN A,et al.Anti-CarP antibodies as promising marker to measure joint damage and disease activity in patients with rheumatoid arthritis[J]. Immunol Res,2015,61(1-2):24-30.
[18]	KAJIYA M,ICHIMONJI L,MIN C,et al.Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation[J].Mol Pharmacol,2012,82(1):115-124.
[19]	罗慧臣,李萍,肖卫国.M3R与AQP5在干燥综合征患者唇腺中的表达与意义[J].中国免疫学杂志,2011,27(1):79-81.
[20]	SHEN L,SURESH L,MALYAVANTHAM K,et al.Different stages of primary Sjögren's syndrome involving lymphotoxin and type 1 IFN[J]. J Immunol,2013,191(2):608-613.
[21]	SHEN L,SURESH L,LI H,et al.IL-14 alpha,the nexus for primary Sjögren's disease in mice and humans[J].Clin Immunol,2009,130(3):304-312.
[22]	VISHWANATH S,EVERETT S,SHEN L,et al.Xerophthalmia of Sjögren's syndrome diagnosed with anti-salivary gland protein 1 antibodies[J].Case Rep Ophthalmol,2014,5(2):186-189.
[23]	WATANABE T,TSUCHIDA T,KANDA N,et al.Anti-alpha-fodrin antibodies in Sjören syndrome and lupus erythematosus[J]. Arch Dermatol,1999,135(5):535-539.
[24]	HE J,FANG W,LI Z G.The application of combined detection of autoantibodies in primary Sjögren's syndrome[J].Zhonghua Nei Ke Za Zhi,2008,47(5):366-368.
[25]	ZANDBELT M M,VOGELZANGS J,VAN D E PUTTE L B,et al.Anti-alpha-fodrin antibodies do not add much to the diagnosis of Sjögren's syndrome[J].Arthritis Res Ther,2004,6(1):R33-R38.
[26]	SORDET C,GOTTENBERG J E,GOETZ J,et al.Anti-alpha-fodrin autoantibodies are not useful diagnostic markers of primary Sjögren's syndrome[J]. Ann Rheum Dis,2005,64(8):1244-1245.
[27]	DUGAR M,COX S,LIMAYE V,et al.Clinical heterogeneity and prognostic features of South Australian patients with anti-synthetase autoantibodies[J].Intern Med J,2011,41(9):674-679.
[28]	MARIE I,LAHAXE L,BENVENISTE O,et al.Long-term outcome of patients with polymyositis/dermatomyositis and anti-PM-Scl antibody[J].Br J Dermatol,2010,162(2):337-344.
[29]	FUJIMOTO M,MURAKAMI A,KUREI S,et al.Enzyme-linked immunosorbent assays for detection of anti-transcriptional intermediary factor-1 gamma and anti-Mi-2 autoantibodies in dermatomyositis[J]. J Dermatol Sci,2016,84(3):272-281.
[30]	张健,宋芹,常虹,等. 多发性肌炎/皮肌炎患者血清抗Jo-1和Mi-2等6种自身抗体检测的意义[J].中国误诊学杂志,2008,8(23):5548-5550.
[31]	HAMAGUCHI Y,KUWANA M,HOSHINO K,et al.Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis:a multicenter cross-sectional study[J].Arch Dermatol,2011,147(4):391-398.
[32]	SATO S,KUWANA M,FUJITA T,et al.Anti-CADM-140/MDA5 autoantibody titer correlates with disease activity and predicts disease outcome in patients with dermatomyositis and rapidly progressive interstitial lung disease[J]. Mod Rheumatol,2013,23(3):496-502.
[33]	HOSHINO K,MUM Y,SUGIURA K,et al.Anti-MDA5 and anti-TIFI-gamma antibodies have clinical significance for patients with dermatomyositis[J].Rheumatology(Oxford),2010,49(9):1726-1733.
[34]	TARGOFF I N,MAMYROVA G,TRIEU E P,et al.A novel autoantibody to a 155-kd protein is associated with dermatomyositis[J].Arthritis Rheum,2006,54(11):3682-3689.