关键词: 同型半胱氨酸, 叶酸, 维生素B12, 高血压

Abstract:

Objective To investigate the clinical significance of homocysteine（Hcy）,folic acid and vitamin B₁₂ （Vit B₁₂） for hypertension and its complications. Methods A total of 4 358 subjects were enrolled and determined for Hcy,folic acid and Vit B₁₂,and other information of healthy examination was collected. According to hypertension and its complications,they were classified into simple hypertension group（653 cases）, hypertension with coronary heart disease（CHD） group（550 cases）, hypertension withs diabetes mellitus（DM） group（386 cases）,hypertension with other disease group（154 cases） and healthy control group（2 615 cases）. Results There were 1 743 cases with hypertension,and its determination rate was 39.99%. The levels of Hcy,Vit B₁₂ and folic acid in healthy control group were normal. The Hcy levels of simple hypertension group,hypertension with CHD group,hypertension with DM group and hypertension with other disease group increased linearly,and the levels of Vit B₁₂ and folic acid decreased linearly. Compared to healthy control group,age,body mass index（BMI）,sex proportion,the rates of tobacco and alcohol abuses,Hcy level and hyperhomocysteinemia rate of the other 4 groups were higher（P<0.05）,and the levels of folic acid and Vit B₁₂ were lower（P<0.05）. Compared to simple hypertension group,the other hypertension groups had higher level of Hcy and hyperhomocysteinemia rate（P<0.05） and lower levels of folic acid and Vit B₁₂（P<0.05）. Compared to hypertension with CHD group,hypertension with DM group and hypertension with other disease group had higher level of Hcy（P<0.05） and lower levels of folic acid and Vit B₁₂（P<0.05）. There was no statistical significance of other comparisons among groups（P>0.05）. Conclusions High level of Hcy,low level of Vit B₁₂ and low level of folic acid are risk factors for hypertension and its complications. Hypertension is associated with age,tobacco and alcohol abuses and BMI.

Key words: Homocysteine, Folic acid, Vitamin B12, Hypertension