关键词: 视黄醇结合蛋白4, 同型半胱氨酸, 血脂, 颈动脉内膜中层厚度, 动脉粥样硬化

Abstract:

Objective To study the relationship of serum retinol binding protein 4（RBP4）,homocysteine（Hcy） and blood lipid with atherosclerosis. Methods According to the carotid intima-medium thickness（IMT）,39 cases were classified into normal carotid IMT group,and 197 cases were classified into increased carotid IMT group. RBP4,Hcy and blood lipids [total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein A1（apo A1） and apolipoprotein B（apo B）] were determined. The correlation between RBP4,Hcy and blood lipids in atherosclerosis group was analyzed. Results The levels of TG,LDL-C,Hcy and RBP4 were higher in increased carotid IMT group than those in normal carotid IMT group（P=0.000）,and HDL-C and apo A1 were lower（P=0.000）. TC and apo B levels had no statistical significance between the 2 groups（P>0.05）. Spearman correlation analysis showed that RBP4 level was positively correlated with TG（r=0.745,P<0.05）,and there were negative correlations with HDL-C（r=-0.727,P<0.05）and apo A1（r=-0.512,P<0.05）. TC was correlated positively with LDL-C（r=0.883,P<0.05） and apo B（r=0.850,P<0.05）,while TG was correlated negatively with HDL-C（r=-0.679,P<0.05） and apo A1（r=-0.336,P<0.05）. The other items had no correlation（P>0.05）. Logistic regression analysis results showed that the regression equations of RBP4 and TG,HDL-C and apoA1 were Y=32.07X-15.30（r=0.745,P<0.05）,Y=-190.84X³+963.61X²-1 493.03X+746.06（r=0.861,P=0.000） and Y=-342.66X³+1 571.76X²-2 372.02X+1 212.93（r=0.670,P=0.000）,respectively. Conclusions RBP4 is associated with blood lipids,while Hcy is not associated with RBP4 and blood lipids. RBP4,Hcy and blood lipids are related to atherosclerosis.

Key words: Retinol binding protein 4, Homocysteine, Blood lipid, Intima-medium thickness, Atherosclerosis