1例套细胞淋巴瘤外周血血涂片细胞形态学特征报道

doi:10.3969/j.issn.1673-8640.2016.08.017

检验医学 ›› 2016, Vol. 31 ›› Issue (8): 709-712.DOI: 10.3969/j.issn.1673-8640.2016.08.017

1例套细胞淋巴瘤外周血血涂片细胞形态学特征报道

须静¹, 梅虹¹, 耿朝辉¹, 郭竹英¹, 陆静峰², 胡晓波³

1.上海交通大学医学院附属第九人民医院（北部）检验科,上海201900
2. 上海交通大学医学院附属第九人民医院（北部）血液科,上海201900
3. 上海中医药大学附属龙华医院检验科,上海 200032

收稿日期:2015-08-02 出版日期:2016-08-31 发布日期:2016-09-01
作者简介:null
作者简介：须静,女,1980年生,学士,主管技师,主要从事临床血液、体液学检验工作。

通讯作者：胡晓波,联系电话：021-64385700。

Report on the morphological characteristics of peripheral blood cell smears from 1 case of mantle cell lymphoma

XU Jing¹, MEI Hong¹, GENG Chaohui¹, GUO Zhuying¹, LU Jingfeng², HU Xiaobo³

1. Department of Clinical Laboratory,Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 201900,China
2. Department of Hematology,Shanghai Ninth People's Hospital North Campus,Shanghai Jiaotong University School of Medicine,Shanghai 201900,China
3. Department of Clinical Laboratory,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China

Received:2015-08-02 Online:2016-08-31 Published:2016-09-01

摘要/Abstract

摘要：

目的套细胞淋巴瘤（MCL）是一类较少见的非霍奇金淋巴瘤（NHL）,临床上易误诊和漏诊,为提高对MCL的认识,我们报告了近期发现的1例MCL外周血血细胞形态学特征。方法回顾性总结本例MCL患者临床资料和实验室检查特点,并与慢性淋巴细胞白血病相鉴别。结果本例MCL患者外周血血细胞形态学结合免疫表型和染色体检查特征,发现MCL患者淋巴瘤细胞形态具有特征性表现,其形态比正常小淋巴细胞稍大,核多数不规则,有切迹,染色质松散,可见小核仁,胞质很少至较少。结论 MCL诊断虽取决于淋巴结活检、细胞遗传学和分子生物学等检查,但外周血血细胞形态常在初诊筛检时价值很高。

关键词: 套细胞淋巴瘤, 流式细胞术, 细胞形态学特征

Abstract:

Objective Mantle cell lymphoma（MCL） is a rare class of non-Hodgkin's lymphoma（NHL）. It is often misdiagnosed and missed diagnosis clinically. The article reports the recent findings about the morphological characteristics of peripheral blood cell smears from 1 case of MCL. Methods The clinical data and laboratory determination characteristics of the case of MCL were reviewed,retrospectively,and were analyzed with those of chronic lymphocytic leukemia. Results It was found that the morphology of lymphoma cells in the case of MCL was characterized through peripheral blood cell morphology,immunophenotype and chromosome examination. Its shape was slightly larger than those of normal small lymphocytes,and most nuclei were observed with irregularity,notch,chromatin loose,small nucleoli and cytoplasm rarely to less. Conclusions Although the diagnosis of MCL depends on lymph node biopsy,cell genetics and molecular biology,the morphology of peripheral blood cells is of significance in initial screening.

Key words: Mantle cell lymphoma, Flow cytometry, Cell morphological characteristics

中图分类号:

R446.1

须静, 梅虹, 耿朝辉, 郭竹英, 陆静峰, 胡晓波. 1例套细胞淋巴瘤外周血血涂片细胞形态学特征报道[J]. 检验医学, 2016, 31(8): 709-712.

XU Jing, MEI Hong, GENG Chaohui, GUO Zhuying, LU Jingfeng, HU Xiaobo. Report on the morphological characteristics of peripheral blood cell smears from 1 case of mantle cell lymphoma[J]. Laboratory Medicine, 2016, 31(8): 709-712.

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1例套细胞淋巴瘤外周血血涂片细胞形态学特征报道

Report on the morphological characteristics of peripheral blood cell smears from 1 case of mantle cell lymphoma

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