纳米场效应晶体管生物传感器在医学检测中的应用

doi:10.3969/j.issn.1673-8640.2015.06.025

摘要/Abstract

摘要：

通过纳米材料与生物传感元件结合来选择性地识别生物分子推动了纳米生物传感器的发展。纳米场效应晶体管生物传感器是近年来发展起来的一种新型生物传感平台,与传统的检测技术相比,它具有以下几个重要的优势,如灵敏度和选择性高、分析速度快、免标记、操作简单等。文章概述了基于石墨烯、硅纳米线和碳纳米管等纳米材料的场效应晶体管生物传感器的工作原理、制备方法及其在医学检测中的应用。

关键词: 生物传感器, 纳米材料, 场效应晶体管, 医学检测, 应用

Abstract:

The combination of nanomaterials and biosensing elements to selectively recognize biological molecules promotes the development of nanobiosensors. Nanomaterial-based field effect transistor biosensors are one of newly developed biosensing technologies. Compared with the conventional detection technologies, they offer several important advantages including high sensitivity and selectivity, rapid analysis, label-free detection, easy operation and so on. This review summarizes the working principle and fabrication of field effect transistor biosensors based on graphene, silicon nanowires and carbon nanotubes and their applications in medicine detection.

Key words: Biosensor, Nanomaterial, Field effect transistor, Medical detection, Application

中图分类号:

R446

蔡冰洁, 张国军. 纳米场效应晶体管生物传感器在医学检测中的应用[J]. 检验医学, 2015, 30(6): 650-654.

CAI Bingjie, ZHANG Guojun. Application of nanomaterial-based field effect transistor biosensor in medical detections[J]. Laboratory Medicine, 2015, 30(6): 650-654.

图/表 4

图1 纳米FET生物传感器的结构及原理示意图

图2 R-GO场效应晶体管生物传感器检测DNA的原理示意图[5]

图3 CHUA等[16]构建的新型硅纳米线FET生物传感器

图4 基于竞争结合的碳纳米管FET生物传感器的原理图[25]

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