代谢综合征及其风险因子对血清前列腺特异性抗原水平的影响

doi:10.3969/j.issn.1673-8640.2014.09.016

检验医学 ›› 2014, Vol. 29 ›› Issue (9): 940-944.DOI: 10.3969/j.issn.1673-8640.2014.09.016

代谢综合征及其风险因子对血清前列腺特异性抗原水平的影响

张本宏¹,章飞²,陈保德³,许颂霄⁴,成海恩⁵

1. 杭州市拱墅区中西医结合医院,浙江杭州 310000;
2. 上海理工大学,上海 200093;
3. 浙江大学附属第一医院,浙江杭州 310003;
4. 浙江大学附属邵逸夫医院,浙江杭州 310016;
5. 浙江大学附属第二医院,浙江杭州 310009

收稿日期:2014-01-07 出版日期:2014-09-30 发布日期:2014-09-25
通讯作者: 陈保德,联系电话:0571-87236382
作者简介:张本宏,男,1973年生,学士,主要从事临床检验工作

The influence of metabolic syndrome and its risk components on serum prostate-specific antigen level

ZHANG Benhong¹, ZHANG Fei², CHEN Baode³, XU Songxiao⁴, CHENG Haien⁵

1. Integrated Chinese and Western Medicine Hospital of Gongshu District,Zhejiang Hangzhou 310000,China;
2. Shanghai University for Science and Technology, Shanghai 200093, China;
3. The First Affiliated Hospital of Zhejiang University,Zhejiang Hangzhou 310003, China;
4. Sir Run Run Shaw Hospital, Zhejiang University, Zhejiang Hangzhou 310016, China;
5. The Second Affiliated Hospital of Zhejiang University, Zhejiang Hangzhou 310009, China

Received:2014-01-07 Online:2014-09-30 Published:2014-09-25

摘要/Abstract

摘要： 目的了解代谢综合征及其风险因子对血清前列腺特异性抗原(PSA)水平的影响。方法选取3家医院体验中心40岁以上无前列腺癌病史、符合标准且资料完整的男性健康体检者5 717名,行体格检查并测定相关的生化指标[甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和空腹血糖(FBG)]和PSA,以中华医学会糖尿病学分会(CDS)2007年标准定义代谢综合征及其风险因子,统计分析代谢综合征及其风险因子对血清PSA水平的影响。结果 5 717名健康体检者年龄为(53.49±10.64)岁,代谢综合征患者占27.1%,PSA为(1.04±0.72) ng/mL。代谢综合征组与非代谢综合征组间PSA水平差异无统计学意义(P>0.05)。在控制年龄的偏相关性分析中,体重指数(BMI)、FBG与PSA水平呈负相关[相关系数(r)分别为-0.05和-0.03,P<0.05];代谢综合征及其它风险因子与PSA无相关性(P>0.05)。在校正年龄的协方差分析中,按BMI和FBG水平分组,随着BMI或FPG水平的增加,校正年龄后的对数PSA值逐渐降低。结论代谢风险因子中超重和高血糖与血清PSA水平呈负相关。在临床解释PSA水平时,应考虑BMI和血糖水平对PSA水平的影响。

关键词: 前列腺特异性抗原, 代谢综合征, 前列腺肿瘤

Abstract: Objective To investigate the influence of metabolic syndrome and its risk components on serum prostate-specific antigen(PSA) level. Methods A total of 5 717 male healthy subjects over 40 years old without the history of prostate cancer, who met the requirements and had integrated data, were enrolled from 3 hospitals.Physical examination and laboratory tests [triglyceride (TG), high-density lipoprotein cholesterol(HDL-C), fasting blood glucose(FBG)and PSA]were performed. According to Chinese Diabetes Society criteria for metabolic syndrome and its risk components, the influence of metabolic syndrome and its risk components on serum PSA level was analyzed statistically. Results The mean age of 5 717 healthy subjects was (53.49±10.64)years old, the prevalence of metabolic syndrome was 27.1%, and the PSA was (1.04±0.72) ng/mL. The PSA levels between metabolic syndrome group and healthy control group were not significantly statistical (P>0.05). After adjusting for age, the partial correlation among body mass index (BMI), FBG and PSA levels was negative, and the correlation coefficients(r) were -0.05 and -0.03, respectively(P<0.05). There was no correlation between metabolic syndrome and its risk components with serum PSA (P>0.05).For analysis of covariance, the age-adjusted means of serum PSA levels by BMI and FBG were cmputed, and they decreased with the increase of BMI and FBG. Conclusions The correlation of serum PSA level with BMI and FBG is negative. The influence of BMI and FBG on PSA level should be considered.

Key words: Prostate-specific antigen, Metabolic syndrome, Prostate tumor

中图分类号:

R446.1

张本宏,章飞,陈保德,许颂霄,成海恩. 代谢综合征及其风险因子对血清前列腺特异性抗原水平的影响[J]. 检验医学, 2014, 29(9): 940-944.

ZHANG Benhong, ZHANG Fei, CHEN Baode, XU Songxiao, CHENG Haien. The influence of metabolic syndrome and its risk components on serum prostate-specific antigen level[J]. , 2014, 29(9): 940-944.

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代谢综合征及其风险因子对血清前列腺特异性抗原水平的影响

The influence of metabolic syndrome and its risk components on serum prostate-specific antigen level

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