关键词: 低相对分子质量肝素, 血栓弹力图, 抗Xa活性

Abstract: Objective To attempt to use thromboelastography (TEG) reaction time (R) to monitor the clinical use of low molecular weight heparin (LMWH). Methods A total of 20 hospitalized patients from nephrology department with nephritic syndrome were enrolled.Blood samples were collected at 4 h after both firstly and secondly receiving dose in order to perform TEG and anti-Xa activity test. TEG R and anti-Xa activity were determined. The associations between TEG R and anti-Xa activity, between the dose of taking drugs at first time and anti-Xa activity, and between the dose of taking drugs at first time and TEG R, were analyzd. The comparative analysis of anti-Xa activity with different doses of taking drugs was performed. The comparative analysis of TEG R with different doses of taking drugs was performed. Results There was no association between TEG R and anti-Xa activity (P=0.54, R=-0.144 9). There was no association between anti-Xa activity and the dose of taking drugs at first time (P=0.26, R=-0.263 6). There was obvious association between TEG R and the dose of taking drugs at first time (P<0.000 1, R=0.875). There was difference in anti-Xa activity between the 2 doses of taking drugs (P=0.000 5, t=4.152). There was significant difference in TEG R between the 2 doses of taking drugs (P<0.000 1, t=15.19). Conclusions TEG R reflects patients' condition of using LMWH much more accurately than anti-Xa activity.

Key words: Low molecular weight heparin, Thromboelastography, Anti-Xa activity