检验医学 ›› 2014, Vol. 29 ›› Issue (4): 328-330.DOI: 10.3969/j.issn.1673-8640.2014.04.007

• 临床应用研究·论著 • 上一篇    下一篇

射频导管消融术后部分凝血与纤溶指标的变化

崔凡   

  1. 芜湖市第一人民医院检验科,安徽 芜湖 241000
  • 收稿日期:2012-12-19 出版日期:2014-04-30 发布日期:2014-06-06
  • 作者简介:崔凡,男,1968年生,硕士,主任技师,主要从事临床生化、分子生物学检验工作。

The changes of blood coagulation and fibrinolytic indices after radiofrequency catheter ablation

CUI Fan.   

  1. Department of Clinical Laboratory, the First People′s Hospital of Wuhu, Anhui Wuhu 241000, China
  • Received:2012-12-19 Online:2014-04-30 Published:2014-06-06

摘要:

目的 观察射频导管消融术(RFCA)对患者术后部分凝血与纤溶指标变化的影响,以及术后恢复时间。方法 对56例接受RFCA治疗的患者,在RFCA前、心内电生理检查后、成功消融后即刻、术后第2天和第7天抽取静脉血,测定D-二聚体(DD)、血管内血友病因子(vWF)、血浆组织纤溶酶原(t-PA)和组织纤溶酶原抑制物(PAI-1)含量。结果 与术前比较,血浆DDvWF浓度以及血浆PAI-1含量在心内电生理检查后、消融成功后即刻和术后第2天均显著上升(P0.01),并于第7天降至术前水平(P>0.05),而t-PA含量在心内电生理检查后,消融成功后即刻和术后第2天显著下降(P0.01),并于第7天降至术前水平(P>0.05)。结论 RFCA可引起血液中部分凝血与纤溶物质水平显著增加,术前、术后对其监测有利于指导抗凝药物应用和预防血栓栓塞的发生。

关键词: D-二聚体, 血管内血友病因子, 组织纤溶酶原, 组织纤溶酶原抑制物, 射频导管消融术

Abstract:

Objective To observe the changes of blood coagulation and fibrinolytic indices after radiofrequency catheter ablation(RFCA) and the restoring time after RFCA. Methods The levels of D-dimer (DD), von willebrand factor (vWF), tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) were determined in 56 patients undergoing RFCA after intracardiac electrophysiological study before RFCA, just at the time after RFCA and in 2 d and 7 d after RFCA. Results The levels of DD, vWF and PAI-1 increased significantly after intracardiac electrophysiological study before RFCA, just at the time after RFCA and in 2 d after RFCA (P<0.01), and restored in 7 d after RFCA (P>0.05). The t-PA decreased significantly after intracardiac electrophysiological study before RFCA, just at the time after RFCA and in 2 d after RFCA (P<0.01), and restored in 7 d after RFCA (P>0.05). Conclusions RFCA may increase the levels of blood coagulation and fibrinolytic indices. Monitoring the levels of D-dimer, vWF, t-PA and PAI-1 is valuable in guiding the administration of anticoagulative drugs and the prophylaxis of thromboembolic events.

Key words: D-dimer, Von willebrand factor, Tissue plasminogen activator, Plasminogen activator inhibitor, Radiofrequency catheter ablation

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