儿童肾病综合征患者血清视黄醇结合蛋白4水平与氧化低密度脂蛋白的关系研究

doi:10.3969/j.issn.1673-8640.2014.02.008

检验医学 ›› 2014, Vol. 29 ›› Issue (2): 122-129.DOI: 10.3969/j.issn.1673-8640.2014.02.008

儿童肾病综合征患者血清视黄醇结合蛋白4水平与氧化低密度脂蛋白的关系研究

牛冬梅, 洪骏, 吴嘉, 宋佳希, 于瑞杰, 袁云龙, 汪俊军

南京军区南京总医院全军临床检验医学研究所, 江苏南京 210002

收稿日期:2013-07-25 出版日期:2014-02-20 发布日期:2014-02-20
通讯作者: 汪俊军, 联系电话:025-80860181
作者简介:牛冬梅, 女, 1982年生, 本科, 技师, 主要研究方向为临床脂质研究。
基金资助:
国家自然科学基金资助项目(81271904);南京军区南京总医院院课题(2013025)

Research on relationship between the levels of serum retinol binding protein 4 and oxidized-low density lipoprotein in children with nephrotic syndrome

NIU Dongmei, HONG Jun, WU Jia, SONG Jiaxi, YU Ruijie, YUAN Yunlong, WANG Junjun.

Institute of Laboratory Medicine Science of the People′s Liberation Army, Nanjing General Hospital of Nanjing Military Command, Jiangsu Nanjing 210002, China

Received:2013-07-25 Online:2014-02-20 Published:2014-02-20

摘要/Abstract

摘要：

目的探讨儿童肾病综合征(NS)患者血清视黄醇结合蛋白4(RBP4)水平的变化及其与氧化低密度脂蛋白(ox-LDL)的关系。方法分别检测118例NS患儿和45名健康体检儿童(正常对照组)血清RBP4水平, 同时测定其血清ox-LDL、白蛋白(Alb)、血脂[包括总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及非高密度脂蛋白胆固醇(non HDL-C)]及肾功能指标[尿素(Urea)、肌酐(Cr)], 并做统计学分析。结果 NS组血清RBP4水平为(55.88±27.36)mg/L, 明显高于正常对照组[(30.61±8.68)mg/L](P<0.01), 且血清RBP4与ox-LDL、TC、TG、LDL-C、non HDL-C及Urea呈明显正相关[相关系数(r)分别为0.30、0.35、0.25、0.29、0.32、0.26, P均＜0.01];进一步多元回归分析显示, NS组TC(β=0.62, P<0.01)、Urea(β=0.26, P<0.01)和ox-LDL(β=0.20, P<0.05)水平共同影响了48.4%的RBP4的变化, 且RBP4也是NS患儿ox-LDL水平的决定因素之一。结论 NS患儿血清RBP4水平明显升高。升高的RBP4与ox-LDL的增加有一定的关联, 可能促进了NS的发生、发展。

关键词: 视黄醇结合蛋白4, 氧化低密度脂蛋白, 脂质代谢, 儿童肾病综合征

Abstract:

Objective To investigate the relationship between the level change of serum retinol binding protein 4(RBP4) and oxidized-low density lipoprotein(ox-LDL) in children with nephrotic syndrome(NS). Methods The levels of serum RBP4 in 118 children with NS(NS group) and 45 healthy children(healthy control group) were determined respectively, the levels of ox-LDL, albumin (Alb), blood lipids [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non HDL-C] andrenal function parameters [urea and creatinine (Cr)] were determined simultaneously, and the results were analyzed statistically. Results The levels of serum RBP4 in NS group [(55.88±27.36)mg/L] were significantly higher than those in healthy control group [(30.61±8.68) mg/L] (P<0.01). The levels of serum RBP4 were positively correlated with ox-LDL, TC, TG, LDL-C, non HDL-C and urea [correlation coefficient (r)=0.30, 0.35, 0.25, 0.29, 0.32 and 0.26, P<0.01].Multiple linear regression analysis found that the changes of TC(β=0.62, P<0.01), urea(β=0.26, P<0.01) and ox-LDL(β=0.20, P<0.05) influenced the 48.4％ of the change of RBP4. In addition, RBP4 was one of factors for the levels of ox-LDL in children with NS. Conclusions The levels of serum RBP4 in children with NS increase significantly, which are associated with the increase of ox-LDL, promoting the occurrence and development of NS.

Key words: Retinol binding protein 4, Oxidized-low density lipoprotein, Lipid metabolism, Child nephrotic syndrome

中图分类号:

R446.1

牛冬梅, 洪骏, 吴嘉, 宋佳希, 于瑞杰, 袁云龙, 汪俊军. 儿童肾病综合征患者血清视黄醇结合蛋白4水平与氧化低密度脂蛋白的关系研究[J]. 检验医学, 2014, 29(2): 122-129.

NIU Dongmei, HONG Jun, WU Jia, SONG Jiaxi, YU Ruijie, YUAN Yunlong, WANG Junjun.. Research on relationship between the levels of serum retinol binding protein 4 and oxidized-low density lipoprotein in children with nephrotic syndrome[J]. , 2014, 29(2): 122-129.

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儿童肾病综合征患者血清视黄醇结合蛋白4水平与氧化低密度脂蛋白的关系研究

Research on relationship between the levels of serum retinol binding protein 4 and oxidized-low density lipoprotein in children with nephrotic syndrome

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