检验医学 ›› 2013, Vol. 28 ›› Issue (7): 602-605.DOI: 10.3969/j.issn.1673-8640.2013.07.010

• 临床应用研究.论著 • 上一篇    下一篇

2 425例小儿呼吸道感染7种常见病毒检出情况分析

张雪清, 胡 骏, 宁小晓, 高淑芳, 王 蕾   

  1. 上海中医药大学附属龙华医院检验科,上海 200032
  • 收稿日期:2013-07-29 修回日期:2013-07-29 出版日期:2013-07-25 发布日期:2013-07-29
  • 通讯作者: 王 蕾,联系电话:021-64385700-3206
  • 作者简介:张雪清,女,1981年生,学士,技师,主要从事临床微生物检验工作。

Analysis on the detection situation of 7 common viruses in 2 425 children with respiratory tract infection

ZHANG Xueqing,HU Jun,NING Xiaoxiao,GAO Shufang,WANG Lei   

  1. Department of Clinical Laboratory,Longhua Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
  • Received:2013-07-29 Revised:2013-07-29 Online:2013-07-25 Published:2013-07-29

摘要: 目的 分析急性下呼吸道感染患儿7种常见病毒[副流感病毒Ⅰ(PIVⅠ)、 副流感病毒Ⅱ(PIVⅡ)、 副流感病毒Ⅲ(PIVⅢ)、呼吸道合胞病毒(RSV)、流感病毒A(IVA)、流感病毒B(IVB)、腺病毒(ADV)]的感染情况。方法 收集2 425例急性呼吸道感染的住院患儿鼻咽深部分泌物标本,进行呼吸道病毒7项指标检测,从患儿年龄[婴幼儿(≤3岁)1 526例、学龄前儿童(4~7岁)650例、儿童(≥8岁)250例]、病毒分布情况、季节因素等方面进行临床流行病学特点分析。 结果 2 425例患儿中有552例7种呼吸道病毒阳性,总阳性率为22.76%;其中单一病毒感染360例(65.22%)、混合病毒感染192例(34.78%);在各年龄组中婴幼儿组感染者377例(68.29%),其中单病毒感染242例(43.84%)、混合病毒感染135例(24.46%)。7种病毒中PIVⅢ感染最多,为196例(35.51%),其次为RSV[183例(33.15%)]。从季节分布来看,春、夏、秋、冬四季的检出率分别为17.79%、19.73%、22.37%、31.01% ,以冬季阳性率为最高。 结论 PIVⅢ感染是本地区小儿呼吸道病毒感染的主要病毒;≤3岁患儿呼吸道病毒感染率最高;以冬季为呼吸道病毒感染高发期。

关键词: 副流感病毒, 呼吸道合胞病毒, 流感病毒, 腺病毒, 呼吸道感染, 儿童

Abstract: Objective To analyze the infection situation of 7 common viruses [parainfluenza virus Ⅰ(PIVⅠ),parainfluenza virus Ⅱ(PIVⅡ),parainfluenza virus Ⅲ(PIVⅢ),respiratory syncytial virus (RSV),influenza virus A (IVA),influenza virus B (IVB) and adenovirus (ADV)] among children with acute lower respiratory tract infection. Methods Nasopharyngeal secretion was collected from 2 425 hospitalized children with acute respiratory tract infection,and 7 respiratory viruses were detected to analyze the clinical epidemiological characteristics by age group [1 526 cases of infants(≤3 years old),650 cases of preschools(4-7 years old) and 250 cases of children(≥8 years old)],virus distribution and seasons. Results Among 2 425 children,552 cases were shown to be positive for 7 viruses which included 360 cases of single virus infection (65.22%) and 192 cases of mixed infection(34.78%). The total positive rate was 22.76%. In different age groups,the number of infected infants were 377 cases (68.29%),including 242 cases of single virus infection (43.84%) and 135 cases of mixed infection (24.46%). Among the 7 viruses, the infections were mainly related to PIVⅢ infection with 196 cases (35.51%),followed by RSV infection [183 cases (33.15%)]. In 4 seasons, the positive rates were 17.79%(spring),19.73%(summer),22.37%(autumn) and 31.01%(winter), respectively. The positive rate in winter was the highest. Conclusions PIVⅢ is the major virus in children with respiratory tract infection. The respiratory tract viral infection rate in infants (≤3 years old) is the highest. The respiratory viruses are most prevalent in winter.

Key words: Parainfluenza virus, Respiratory syncytial virus, Influenza virus, Adenovirus, Respiratory tract infection, Child

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