Abstract:

Objective To analyze the changes and clinical value of blood coagulation indexes in infected children with different primary diseases. Methods From January 2021 to December 2022，3 932 infected children（infected group） and 3 932 uninfected children with corresponding primary diseases（uninfected group） were enrolled from Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine，and 3 932 healthy children （healthy control group）were enrolled for coagulation function determination. The difference of relevant indexes between infected group and healthy control group was compared. Results Compared with healthy control group，prothrombin time（PT），activated partial thromboplastin time（APTT） and thrombin time（TT） were prolonged，fibrin/fibrinogen degradation product（FDP） and D-dimer（DD） were increased，and antithrombin-Ⅲ（AT-Ⅲ） activity was decreased in infected group（P<0.05）. There was no statistical significance in fibrinogen（Fib）（P>0.05）. The levels of PT，APTT，TT，Fib，FDP and DD were different in children infected with diseases of cardiovascular system，urinary system，abdominal system and blood system. AT-Ⅲ activity was decreased after infection in children with hematological diseases（P<0.05）. AT-Ⅲ activity in children with severe pneumonia was lower than that in children without severe pneumonia（P<0.05）. Conclusions Blood coagulation indexes have certain value for the diagnosis of infection in children，and the infection status of children with different diseases can be monitored according to the relevant blood coagulation indexes.

Key words: Coagulation function, Coagulation index, Infection, Children, Diagnosis