Abstract:

Objective To investigate the clinical role of high-fluorescent cell（HFC） and serum ascites albumin gradient（SAAG） in the diagnosis of malignant ascites. Methods Totally,202 patients with ascites were enrolled. The patients were classified into malignant group（36 cases）and benign group（166 cases）according to the results of exfoliative cytology. The distribution of HFC and SAAG in the 2 groups was analyzed,and the efficiency of single and combined determinations was evaluated. Results The levels of the absolute value of high-fluorescent cell（HF#） and the percentage of high-fluorescent cell（HF%） in malignant group were higher than those in benign group（P=0.000 0、P=0.000 1）,and the level of SAAG was lower than that in benign group（P=0.000 0）. The areas under curves of HF#,HF% and SAAG for the diagnosis of malignant ascites were 0.797,0.704 and 0.770,respectively. The sensitivities,specificities and accuracies of HF# and SAAG single determinations were 83.3%,66.9%,69.8% and 88.9%,62.1%,66.8%,respectively. The sensitivity,specificity and accuracy of HF# and SAAG combined determination in series were 77.8%,80.1%,79.7%,respectively. The sensitivity,specificity and accuracy of HF# and SAAG combined determination in parallel were 94.4%,48.8%,56.9%,respectively. Conclusions Although the sensitivity decreases after HFC and SAAG combined determination,the specificity and accuracy are both increased,which is more conducive to the diagnosis of malignant ascites.

Key words: High-fluorescent cell, Serum ascites albumin gradient, Malignant ascites