Abstract:

Objective To analyze the clinical symptoms and laboratory determination results of 92 patients with corona virus disease 2019（COVID-19）. Methods The clinical symptoms,diagnosis and classification data of 92 patients with COVID-19 were analyzed retrospectively. The results of the first-time laboratory determination results [white blood cell（WBC） count,the absolute value of neutrophil（NEUT #）,the absolute value of lymphocyte（LYMPH #）,CD3⁺ cell,CD4⁺ cell,CD8⁺ cell,C-reactive protein（CRP）,serum amyloid A（SAA） and Mycoplasma pneumoniae（MP） antibody] were collected. Results Among the 92 patients,there were 35 patients in severe group and 57 patients in mild group. The clinical symptoms of visit were mainly fever（77.2%）,cough（66.3%） and general fatigue（26.1%）,of which cough was mainly coughing white foamy sputum（41.0%） and dry cough（36.1%）. The first clinical symptoms were cough and fever with cough. Totally,80.7% patients had normal WBC count,84.2% had normal NEUT#,and 80.7% had normal LYMPH#. CD3⁺ cell,CD4⁺ cell and CD8⁺ cell decreased in 59.3%,56.0% and 51.6% patients,respectively. CRP was increased in 64.1% patients,SAA was increased in 72.8% patients,and MP antibody was positive in 55.7% patients. NEUT#,CRP and SAA in severe group were higher than those in mild group（P<0.05）,and LYMPH# and CD3⁺ cell,CD4⁺ cell and CD8⁺ cell were lower（P<0.05）. Conclusions It is necessary to be alert to patients whose the first clinical symptom is only cough without fever or cough first and then fever. Laboratory determination indicators（NEUT#,LYMPH#,CRP,SAA,CD3⁺ cell,CD4⁺ cell and CD8⁺ cell） can help clinicians to identify critically ill patients as soon as possible.

Key words: Corona virus disease 2019, Clinical symptom, Laboratory determination indicator