Abstract:

Objective To investigate the roles of serum biotin,vitamin B₁₂（Vit B₁₂） and folic acid（FA） in premature white hair disease. Methods A total of 80 patients with premature white hair disease and 80 healthy subjects（healthy control group） were enrolled. Their general data [sex,age,body mass index（BMI）,total protein（TP）,albumin（Alb）,albumin/globulin（A/G） ratio,fasting blood glucose,total cholesterol（TC）,total bilirubin（TB）,alkaline phosphatase（ALP）,calcium,phosphorus and so on] were collected,and serum biotin,Vit B₁₂ and FA were determined. Graying severity score（GSS） was used for evaluating patients with premature white hair disease,and the difference of Vit B₁₂ and FA deficiency proportions in different GSS groups was compared. Results There was no statistical significance in sex,age,BMI,TP,Alb,A/G ratio,fasting blood glucose,TC,TB,ALP,calcium and phosphorus levels between the 2 groups（P>0.05）. The levels of biotin,Vit B₁₂ and FA in premature white hair disease group were lower than those in healthy control group（P<0.05）. Among the 80 patients with premature white hair disease,there were 30 cases of GSS mild,42 cases of GSS moderate and 8 cases of GSS severe. There were 10（33.33%）,22（52.38%） and 8（100.00%） cases of Vit B₁₂ deficiency in GSS mild,moderate and severe groups,respectively,and there were 4（13.33%）,13（30.95%） and 4（50.00%） cases of FA deficiency,respectively. The proportions of Vit B₁₂ deficiency and FA deficiency increased with the increase of GSS in patients with premature white hair disease. There was statistical significance for the proportion of Vit B₁₂ deficiency among different GSS groups（P<0.05）,and there was no statistical significance for the proportion of FA deficiency （P>0.05）. Conclusions Serum biotin,Vit B₁₂ and FA are related to premature white hair disease.

Key words: Biotin, Vitamin B₁₂, Folic acid, Premature white hair disease