Relationship between serum uric acid and red blood cell parameters in hyperuricemia patients

doi:10.3969/j.issn.1673-8640.2019.06.002

Abstract

Abstract:

Objective To investigate the relationship between serum uric acid（UA） and red blood cell（RBC） parameters in hyperuricemia（HUA） patients. Methods A total of 1 168 HUA patients（HUA group） and 1 311 healthy subjects（healthy control group） were enrolled. The results of UA,RBC count,hemoglobin（Hb）,mean corpuscular hemoglobin（MCH）,mean corpuscular hemoglobin concentration（MCHC）,red blood cell distribution width（RDW） and mean corpuscular volume（MCV） were collected. All the research subjects were classified into male and female groups,and HUA group was sub-classified according to the quartiles of UA. The relationship betweeen UA and RBC parameters was analyzed by Pearson analysis,multiple binary Logistic analysis and multiple linear regression analysis. Results The levels of UA, MCH,MCHC,RBC count and Hb were higher in HUA group than those in healthy control group for males（P<0.05）. The levels of UA,MCH,RDW,RBC count and Hb were higher in HUA group than those in healthy control group for females（P<0.05）,and the level of MCV was lower（P<0.001）. The increased RBC count was related with the increasing of UA levels for males and females（P<0.001）,and the decreased RDW level was related with the increasing of UA levels for males（P<0.05）. Pearson analysis showed that there were positive correlations between UA and RBC count in males（r=0.119,P=0.002） and in females（r=0.180,P<0.001）. There was a negative correlation between UA and RDW in males（r=-0.017,P=0.005）. Multiple binary Logistic analysis showed that the UA levels of male HUA patients with UA>0.46-0.49 mmol/L and UA>0.49 mmol/L were independent factors for the decreasing of RDW level [odds ratio（OR）=0.773 and 0.690,respectively] and the increasing of RBC count（OR=1.938 and 1.787,respectively）. The UA level of female HUA patients with UA>0.41 mmol/L was the independent factor for the increasing of RBC count（OR=4.578）. Multiple linear regression analysis showed that the level of UA was positively correlated with RBC count in males（B=0.128,P=0.019）. The level of UA was negatively correlated with RDW in males（B=-0.119,P=0.004）. The level of UA was positively correlated with RBC count in females（B=0.296,P<0.001）. Conclusions The increasing of UA level is an independent factor for the increasing of RBC count in patients with HUA.

Key words: Uric acid, Red blood cell, Hyperuricemia, Relationship

CLC Number:

R446.1

MA Zhengyao, GUO Wei, PAN Baishen, WANG Beili. Relationship between serum uric acid and red blood cell parameters in hyperuricemia patients[J]. Laboratory Medicine, 2019, 34(6): 486-490.

Figures/Tables 5

References 12

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组别	例数	UA（mmol/L）	MCH（pg）	MCHC（g/L）	MCV（fL）	RDW（%）	RBC（×1012/L）	Hb（g/L）
HUA组	1 168
男性	686	0.470±0.045**	30.95±1.61*	336.98±11.06*	91.92±4.69	12.93±0.71	4.66±0.44*	143.77±12.39**
女性	482	0.389±0.053**	30.23±1.63**	331.30±13.32	90.05±3.94**	13.02±0.74*	4.30±0.35**	128.15±9.75*
正常对照组	1 311
男性	759	0.321±0.052	30.75±1.54	335.18±11.76	91.80±4.34	12.93±0.70	4.58±0.48	140.75±13.49
女性	552	0.248±0.046	29.82±1.62	331.16±11.61	91.31±3.95	12.89±0.73	4.18±0.38	126.22±9.74

组别	例数	UA（mmol/L）	MCH（pg）	MCHC（g/L）	MCV（fL）	RDW（%）	RBC（×1012/L）	Hb（g/L）
HUA组	1 168
男性	686	0.470±0.045**	30.95±1.61*	336.98±11.06*	91.92±4.69	12.93±0.71	4.66±0.44*	143.77±12.39**
女性	482	0.389±0.053**	30.23±1.63**	331.30±13.32	90.05±3.94**	13.02±0.74*	4.30±0.35**	128.15±9.75*
正常对照组	1 311
男性	759	0.321±0.052	30.75±1.54	335.18±11.76	91.80±4.34	12.93±0.70	4.58±0.48	140.75±13.49
女性	552	0.248±0.046	29.82±1.62	331.16±11.61	91.31±3.95	12.89±0.73	4.18±0.38	126.22±9.74

UA （mmol/L）	例数	年龄（岁）	BMI （kg/m2）	MCH （pg）	MCHC （g/L）	MCV（fL）	RDW（%）	RBC（×1012/L）	Hb （g/L）
≤0.43	176	59.27±11.65	22.53±2.99	31.09±1.72	337.23±11.46	92.24±4.94	13.01±0.69	4.59±0.44	142.55±12.35
>0.43~0.46	174	56.77±10.20	22.27±3.08	30.92±1.70	337.93±11.36	91.55±4.77	13.01±0.71	4.48±0.45	144.19±13.66
>0.46~0.49	168	57.85±12.74	22.70±2.94	30.96±1.64	335.33±10.68	92.41±4.99	12.85±0.73	4.72±0.43	143.73±12.09
>0.49	168	58.43±12.03	22.48±3.06	30.84±1.26	337.38±10.61	91.46±3.94	12.83±0.69	4.70±0.40	144.65±11.32
F值		1.409	0.607	0.727	1.780	1.775	3.233	11.311	0.921
P值		0.239	0.611	0.536	0.150	0.151	0.022	<0.001	0.430

UA （mmol/L）	例数	年龄（岁）	BMI （kg/m2）	MCH （pg）	MCHC （g/L）	MCV（fL）	RDW（%）	RBC（×1012/L）	Hb （g/L）
≤0.43	176	59.27±11.65	22.53±2.99	31.09±1.72	337.23±11.46	92.24±4.94	13.01±0.69	4.59±0.44	142.55±12.35
>0.43~0.46	174	56.77±10.20	22.27±3.08	30.92±1.70	337.93±11.36	91.55±4.77	13.01±0.71	4.48±0.45	144.19±13.66
>0.46~0.49	168	57.85±12.74	22.70±2.94	30.96±1.64	335.33±10.68	92.41±4.99	12.85±0.73	4.72±0.43	143.73±12.09
>0.49	168	58.43±12.03	22.48±3.06	30.84±1.26	337.38±10.61	91.46±3.94	12.83±0.69	4.70±0.40	144.65±11.32
F值		1.409	0.607	0.727	1.780	1.775	3.233	11.311	0.921
P值		0.239	0.611	0.536	0.150	0.151	0.022	<0.001	0.430

UA （mmol/L）	例数	年龄（岁）	BMI （kg/m2）	MCH （pg）	MCHC （g/L）	MCV（fL）	RDW（%）	RBC（×1012/L）	Hb （g/L）
≤0.35	176	60.91±12.12	22.47±3.09	29.86±2.05	331.88±18.52	90.01±4.00	12.99±0.78	4.24±0.42	127.36±9.69
>0.35~0.37	174	59.58±12.98	22.70±3.23	29.74±1.36	330.92±9.51	89.90±3.78	13.04±0.65	4.30±0.34	127.59±9.23
>0.37~0.41	168	59.46±13.26	22.06±2.71	29.75±1.39	330.34±9.53	90.09±3.81	13.03±0.76	4.32±0.33	128.43±9.32
>0.41	168	61.36±13.41	22.41±3.40	29.93±1.41	331.97±11.18	90.19±4.18	13.04±0.71	4.45±0.32	129.45±10.72
F值		0.632	0.835	0.360	0.434	0.100	0.190	7.080	1.110
P值		0.595	0.475	0.782	0.729	0.960	0.903	<0.001	0.345